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Yasuo Yoshikuni
… engineering, and biosystems design for DOE-mission-relevant discovery and applications. This program has supported over … the JGI, Dr. Yoshikuni also manages the Synthetic Biology Pathway Engineering group. His research focus includes … developing genome engineering tools for non-model organisms, modulating microbe-microbe and plant-microbe …
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Who We Are
… through analyzing and harnessing genomic information from plants, fungi, algae, non-medical microbes, microbial communities, and other relevant organisms. We provide access to large-scale datasets and … and bioproducts. The JGI continues to receive its support from the Biological and Environmental Research program in …
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Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery
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Secrets of the Needles: What Microbes do on Conifer Leaves
… The team learned that some bacterial families carry genes for degrading monoterpenes such as α-pinene, as well as genes for breaking down complex plant polymers. These … some bacterial groups were quite specific to certain hosts, such as the Hymenobacter on Engelmann spruce needles. …
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A Pinch of Salt Activates Silent Gene Clusters in Streptomyces
… Streptomyces are nature's chemical factories. They hold genetic blueprints for dozens of complex compounds, but stay … coelicolor to activate multiple chemical production pathways. By tracking gene activity and chemical output over … chemistry in their organisms of interest — accelerating discovery of bio-based chemicals and materials that …
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GenomeOcean Leverages AI to Decode Nature’s Secret Language
… discoveries. Unlocking the intricate details of life’s genetic blueprint has long been a significant challenge in … machines. It has been applied in a variety of industries, from the health care to the financial sector — whether to … to draft strands encoded with new proteins or genetic pathways not observed in nature. Because of its enhanced …
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Cell-free synthetic biology for natural product biosynthesis and discovery
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Identification of a gene encoding the last step of the L-rhamnose catabolic pathway in Aspergillus niger revealed the inducer of the pathway regulator
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Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III
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Fungal Friends or Foes in Plant Roots
… fungi that colonize Arabidopsis thaliana roots with genomes from other plant-associated fungi. Their analysis identified fungal gene families that help determine if these fungi act as … culture collection consisting of fungal species from natural Arabidopsis populations around Europe. The JGI …
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Marchantia Pangenome Highlights Adaptive Nature of Plant Lineages
… Understanding the shared genetic toolkit of ancestral and present-day plants The Science In a recent  Nature Genetics paper , researchers focused on the full composition of genes, or pangenome, of the model plant  Marchantia … no. DE-AC02-05CH11231. This project received funding from the European Research Council under the European …
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From Intern to Published Scientist: The Journey of a JGI-UC Merced Intern
… current PhD student, reached this milestone with a recent publication in Molecular Biology and Evolution . “It’s my … a quest to better understand the factors and mechanics of gene expression in over 400 fungi species. “Fungi are the … covering the entire kingdom of fungi. “The information from this project may also have a practical relevance with …
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