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DAP-seq Drives Robust Mapping of Gene Regulation
… Multi-species assays yield an unprecedented view of plant evolution and adaptation.    Understanding how … Now, with improvements to DNA Affinity Purification Sequencing (DAP-seq), these barriers are falling. As  … provides a robust community dataset of improved quality; deep insights identify the most important binding sites by …
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Leo Baumgart
… his doctoral research in synthetic biology and microfluidics at the University of California, San Diego. As the Sequencing Technology Implementation Lead, he directs a … and plants. His team is also developing single-nuclei sequencing methods to characterize gene regulation at the …
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Doubling Down on Known Protein Families
… online Oct. 11, 2023 in  Nature highlights the vast array of functional diversity of microbes through a novel approach … living everywhere from soils and stomachs to the deep sea are capable of doing a lot of unique things when it … replicating a whole community is impossible.  Metagenomic sequencing allows researchers to study the entire genetic …
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Mapping the Earth’s Hidden Fungal Kingdom
… Leveraging massive comparative genomics to decode millions of mystery genes and lay a future-ready foundation     Over … fungi have spread quietly throughout our planet. From the deepest ocean floors to Antarctic valleys, these organisms … a stark imbalance. More recently evolved fungi within Dikarya, which include familiar mushrooms and yeasts, …
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From Sample Shipments to Sequences – A Tour of the JGI’s Sequencing Pipeline
… viruses — to support scientists around the world. Most of those researchers send their samples in from afar, without ever hearing much about the sequencing lab. So today, Chris Daum walks through the JGI’s sequencing pipeline, where there are freezers with names — …
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Natural Prodcast Episode 24: Jackie Winter and SMC
… Hey, everyone! Welcome to the “Self Promotion Episode” of Natural Prodcast. A little bit of a bonus episode, since I’m off schedule, but this is an … to grow. If you hear Nigel talk, he is very interested in sequencing a lot more natural product-heavy culture …
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Defining a Pan-Genome for Antarctic Archaea
… Analysis of haloarchaeal metagenomes broadens understanding of … hypersaline Antarctic lakes. The Impact By collecting and sequencing dominant haloarchaeal sequences from six … the haloarchaea that thrive in the very salty waters of Deep Lake to better understand how they’ve adapted to these …
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JGI-USCCN Strain Sequencing Opportunity
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Natural Prodcast Episode 3: The Primer, Part 3
… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … and the 90s. And so we started to be able to explore DNA sequencing and actually get to the DNA sequence – sequences … We have a lot more data. Obviously, there’s been a lot of sequencing going on, especially at the JGI and in other …
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Effects of Polar Light Cycle on Microbial Food Web
… Populations of Antarctic lake microbial communities change with the … the natural world. The Impact From the polar regions to the deep ocean, cold environments occupy more space on Earth … over a 10-year period and sent to JGI for metagenomic sequencing. A study  recently published in  Microbiome shows …
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Webinar: MycoCosm Tutorial
… JGI’s  MycoCosm data portal , an interactive collection of sequenced fungal genomes, omics data and comparative … Do you accept oomycetes to be proposed for genome sequencing, or only “true fungi”? A(nswer): Our focus is on … about myxomycetes (Amoebozoa), would you consider them for sequencing? A: We do have 1 Amoebozoan, > Dicyostelium …
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Cultivating Symbiotic Antarctic Microbes
… The Impact The Antarctic lakes are a “treasure trove” of unknown microbes that play critical roles in … biosphere), including the global carbon cycle. The JGI is sequencing large numbers of microbes and microbial … cells, the first member of the Archaea isolated from Deep Lake, the coldest place on Earth known to support life, …
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