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Genome Engineering Enables Rapid Activation of Biosynthetic Gene Clusters. Nat Microbiol. 4(12):2498-2510. doi: …

… carbon captured from the atmosphere in a process that generates energy. The MPI team ultimately aims to develop an … Functional Genomics call, the JGI synthesized library of genes that code for Enoyl-CoA Carboxylase/Reductase (ECR) … in a cell, from capturing and fixing carbon dioxide to generate multi-carbon compounds through a light-driven …

… in natural ecosystems, and functionally explore viral genetic diversity toward innovative biotechnological and …

… of the Institut Pasteur in France, the importance of methanogenesis and the presence of methanogens in nearly all types … well as tools for analysis. “There is evidence that methanogenesis is one of the oldest metabolisms, with the first … its impact on climate along earth history.” Marker genes for diverse methane metabolisms Of the 10 MAGs …

… at the University of California, Davis and UC Santa Barbara generated a list of prokaryotes with fermentative metabolism … IMG data portals to get information about the genomes and genes of the organisms on the list. They also searched IMG/M for all protein-coding genes belonging to each genome. The final dataset – …

… perform functional assessment, host prediction, and phylogenetic analysis. The development of CheckV helps … these sequences may be tainted by the presence of non-viral genes. Up to this point, there has been a lack of fast and … (contigs) of proviruses flanked on one or both sides by genes from the host organism. With the virus-host boundary …

A workflow for capturing the genetic make-up of specific uncultivated microbes from … their genomes. The Impact Despite great strides in generating genome sequences for members of the microbial … including gathering a more complete view of a population’s genetic makeup and identifying viruses interacting with …

… contains about 6% of the human genome . They discovered genes linked to conditions such as cardiovascular disease, … about 2% of the human genome. They were interested in genes involved in repair of DNA damage, and those associated … 3% of the human genome. They wanted to learn about the genes implicated in the development of breast and prostate …

… could have arisen from. DAN UDWARY: OK, so sort of a phylogenetic reconstruction kind of a thing. ALISON NARAYAN: … to test that hypothesis through site-directed mutagenesis, we would end up with dead enzymes. So often, when … is that it gives us a tool to help us– DAN UDWARY: You can generate that data. ALISON NARAYAN: –generate– JACKIE …