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… and state-of-the-art next-generation sequencing to enable biological discovery by the JGI and external DOE … the latest  sequencing technologies has allowed the JGI to increase sequencing output while significantly lowering … for sequencing. They apply Lean Six Sigma practices to process optimization and development approaches, testing …

… further demystify biosynthetic gene clusters.  The Science Microbial secondary metabolites, those molecules not … for growth yet essential for survival, may now be easier to characterize following a proof-of-concept study in which … it with CRISPR.  By employing CRAGE, researchers are no longer limited to using model host microbes; theoretically, …

… with main focus areas being genome variation, transcriptomics and epigenomics. Our work varies in scope from the development of highly customized analysis workflows for new product types, to the development of automated analysis pipelines for …

… a cyanobacterial protein, researchers have new insights into how these ocean photosynthesizers cycle carbon in … fickle, often hiding their function from even the most determined scientist.  Recent work in  Nature Communications … parts, and an idea of their groupings.  One pivotal effort along these lines came from UC Berkeley professor and …

Methane Metabolism. Methane-producing archaea are estimated to produce 500 million tons of methane a year, which is over … recent studies now suggest the gene cluster predates this microbial group. Recently published in the Proceedings of … led us to conclude that our new methanogen did not belong to the Euryarchaeota, the archaeal “superphylum” where …

DNA genomes that co-infect eukaryotic cells along with giant viruses. Virophages are small viruses with … available metagenomic datasets in JGI’s  Integrated Microbial Genomes & Microbiomes (IMG/M) data suite—which … Virus)—for the virophage marker gene MCP, they were able to identify 44,221 total virophage partial sequences, …

Dr. Rokhsar joined the DOE Joint Genome Institute in 2000 as the founding Associate Director for Computational Genomics, and led the computational … IBM Watson Research Center, Yorktown Heights, NY … Publications … 2018 Marthella Foskett Brown Chair, …

Dr. Louie joined the JGI in 2014 to develop the metabolomics program, and in 2019 became … Rocha UN, Shi S, et al. Dynamic root exudate chemistry and microbial substrate preferences drive patterns in … Sci Rep. 2013;3: 1656. … Education … Selected Publications …

The DOE Joint Genome Institute hosted the hybrid “NeLLi 2023 Symposium” delving into the most recent expansions of the Tree of Life and latest … discoveries toward the evolution of cellular complexity and microbial symbiosis. Further, the symposium showcases …

Congratulations to Susannah Tringe , one of eight scientists and engineers who received the 2020 Ernest Orlando Lawrence Award , one of DOE’s highest … was recognized for “advances in sequence-based studies of microbial assemblies, revealing the roles of microbial …

The JGI is eager to work and share our tools with a widening circle of … of desert grasslands to the metabolic savviness of microbial ecosystems at the forest floor and along ocean shores. Their results could bring key insights …

… for the design and maintenance of the Integrated Microbial Genomes (IMG) data warehouse, and integration of genomic and metagenomic data with transcriptomics and proteomics data. …