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… Cas9 needs guide RNA to lead it to the correct sequence to snip — but not all guides are effective. To … Department of Energy Joint Genome Institute (JGI), a DOE Office of Science User Facility. Y. lipolytica is a tantalizing … approach: CRISPR-Cas9 relies on RNA with a short guiding sequence (20 bp) that directs the endonuclease where to cut, …

… workflows for computational analysis and interpretation of sequence data. IMG/M is a web-based platform that provides access to the wealth of public microbiome sequence data and enables the user to analyze these data … with existing bioinformatic methods to bridge the gap from sequence to biology. …