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Doubling Down on Known Protein Families
Using a novel computational approach, researchers confirm … billion proteins with massively parallel computations.”  Guided by JGI scientists, the team embarked on a mission to … sequencing of the samples, without being able to distinguish which gene belongs to each individual microbial species …
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JGI Launches Latest Strategic Plan
For the Joint Genome Institute, the end of 2018 was marked by a celebration of … to the June dedication event of the Integrative Genomics Building—the new home of the JGI and KBase in the heart of …
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FICUS Overview
The Facilities Integrating Collaborations for User Science (FICUS) initiative was … at individual user facilities. A Letter of Intent is required. For accepted proposals, sequencing, synthesis, …
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Genome Insider
Genome Insider is a podcast that showcases the work of JGI collaborators in brief forays, connecting audiences with the people behind … understand — and harness — the superpowers encoded in plants, fungi, microalgae, environmental viruses, and …
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Synthetic Biology Informatics Group
Software engineers in the Synthetic Biology Informatics Group develop, deploy, and maintain software … CRISPR gRNA design tool BOOST , which provides a suite of tools to automate sequence design for assembly by …
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Making a Lichen Together
The Science The humble lichen is a superorganism: one being that is actually comprised of two (or more) … on lichen, an international team led by Daniele Armaleo, a biologist at Duke University, investigated Gray’s Cup … the fungus and alga, either separately or together, on nitrocellulose filters in Petri dishes. The scientists also …
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Plotting a Model for Virus-Host Warfare Deep Below Ground
…   Visualizing a novel, candidate viral genome found in the deep … nitrogen, but the viruses that infect Altiarchaea cause the cells to burst. This action triggers subsurface carbon … Turzynski in Alexander Probst’s lab at the University of Duisburg-Essen and included researchers at the U.S. …
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Enlarging Windows into Understanding Gene Functions
Leo Baumgart and Juna Lee developed two approaches that build upon the DAP-seq technology O’Malley developed. Unique … species to answer questions about how they break down plant materials, which could be useful for industrial biofuel production, and multicellular development. “DAP-Seq is the main source of …
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The Expanding Universe of Methane Metabolisms in Archaea
Metagenome-assembled archaeal genomes provide new insights into an ancient metabolism. Methane is a greenhouse … of the Earth’s atmosphere and regulating the global climate for life to flourish. For Guillaume Borrel and Simonetta Gribaldo of the Institut …
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An Age of CRAGE: Advances in Rapidly Engineering Non-model Bacteria
… improving and applying a method that allows researchers to quickly modify diverse bacterial genomes. In 2019, the … Nature Microbiology an important addition to the synthetic biologist’s toolkit: a technique for  c hassis (or … Blow, and their team have also harnessed CRAGE to create a plant-fertilizing microbiome. In work  reported in  Applied …
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Informatics Advisory Committee
The IAC is chartered by the JGI Chief Informatics Officer (CIO) and reports to the JGI Director. The IAC is chartered to render advice, guidance, and counsel on the effective management and strategic objectives for the JGI’s data science, informatics and information technology (IT) activities and …
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Evolution of a Fungal Gene Expression Regulator
Describing the largest analysis to date of the modified DNA base … Changing an A, C, T or G in a genome sequence can lead to changes in protein structures and functions, but the DNA … than 500 species of fungi. The Impact Interactions between plants and fungi run the gamut from mutually beneficial to …
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