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… snippets of microbial genomes directly from environmental sequence data, by piecing each genome together from large mixtures of genomic sequences. A complementary approach to this is single cell … are first separated, and their genomes then amplified and sequenced individually, offering scientists the opportunity …

… and eukaryotic microbes and viruses in environmental sequence data. Dr. Schulz employs multi-omics (metagenomics, …

Cas9 needs guide RNA to lead it to the correct sequence to snip — but not all guides are effective. To … approach: CRISPR-Cas9 relies on RNA with a short guiding sequence (20 bp) that directs the endonuclease where to cut, … , the scientists thus set out to identify which sgRNA sequences were reliable. In an elegant, quantitative screen, …

The Impact Despite great strides in generating genome sequences for members of the microbial world through bulk … microbes within metagenome samples and associate their sequences with their roles within their environments. … the complex community and then separating out the sequences representing microbes of interest. When the …