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… further demystify biosynthetic gene clusters.  The Science Microbial secondary metabolites, those molecules not … Repeats) is the leading tool for accurately editing genomes, its effectiveness has historically been limited due … that produce them. The Impact Secondary metabolites are microbial compounds produced in response to hardship or …

… characteristics. When they tested the screen method on a microbial community from geothermal hot springs, they … learn more about what microbes are present in any given ecosystem—particularly those that are in low abundances—and … To validate the predicted cellulases from their captured genomes, the team then used DNA synthesis and cloning, …

… 188 of which were shared with previous studies in the same system. With the right functional characterization, those … This work focused on a relatively well-understood model system, so future directions will also include targeting … grasses, like sorghum and switchgrass. We’re optimizing systems now, so that we can get those working,” Cole said.  …