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Boosting Small Molecule Production in Super “Soup”
… Do metabolic pathways from engineered yeasts still work in cell-free environments? … (BDO). To do so, the yeasts received fine-tuning of gene expression through genetic rewiring with CRISPR-Cas9 that … genomics in support of DOE missions related to clean energy generation and environmental characterization and cleanup. …
Learn more
Webinar: PhycoCosm Tutorial
… Learn more about JGI’s  PhycoCosm data portal , an interactive collection of sequenced algal genomes, omics … getting these data on our system. If it’s not based on the gene model, that should be ok generally. We can work with you to re-map the data. If your … genomics in support of DOE missions related to clean energy generation and environmental characterization and cleanup. …
Learn more
Extracting the Secrets of Secondary Metabolites
… CRAGE-CRISPR combo helps further demystify biosynthetic gene clusters.  The Science Microbial secondary metabolites, … for survival, may now be easier to characterize following a proof-of-concept study in which researchers paired … is a technique researchers can use to integrate large genetic payloads directly into diverse microbes. Combining …
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Streamlining Regulon Identification in Bacteria
… RIViT-seq technology could speed up associating transcription factors with their target genes. The Science Regulons are a group of genes that can be turned on or off by the same regulatory …
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Forming Scientific Connections and Building Community
… The 11th cohort of JGI-UC Merced interns pick highlights from their summer experiences. This … here.” Mentor: Lorenzo Aureli Project: “ Exploring the epigenetic basis of pathogenicity in bacteria” Erika Maquiling … Sajeet Haridas & Asaf Salamov Project: “ Improving the JGI fungal mitochondrial annotation pipeline ” Anna Kucherova : …
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Olpidium, The Key to the Origin of Terrestrial Fungi
… Igor Grigoriev from the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User … to terrestrial habitats. The work is part of the JGI’s 1000 Fungal Genomes Project, which aims to provide genomic … with the two publications of the kingdom-wide, multi-gene phylogeny of fungi by James et al. and Sekimoto et al . …
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Busting the Unbreakable Lignin
… of plant components   The Science There are three main ingredients to tackle when it comes to breaking down a … JGI data portals and pipelines helped identify potential genes responsible for lignin deconstruction. (The JGI also … conducted RNA sequencing and alignment to the reference fungal  genome . The study’s pivotal NMR (nuclear magnetic …
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10 From JGI on the 2019 Highly Cited Researchers List
… their 2019 list of Highly Cited Researchers , which includes 10 affiliated with the JGI . The 2019 list focused … to: Project Manager Kerrie Barry, Cross-Field Category Fungal and Algal Program head Igor Grigoriev , Plant & … Genomics Lead Dan Rokhsar , Molecular Biology & Genetics Staff Data Scientist Asaf Salamov, Plant & Animal …
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Boosting Small Molecule Production in Super “Soup”
… Do metabolic pathways from engineered yeasts still work in cell-free environments? … (BDO). To do so, the yeasts received fine-tuning of gene expression through genetic rewiring with CRISPR-Cas9 that … genomics in support of DOE missions related to clean energy generation and environmental characterization and cleanup. …
Learn more
JGI@25: Following Fungi that Pry Apart Plant Polymers
… 25th anniversary. Over the last year, we’ve been revisiting a number of notable achievements that showcase our … for anaerobic fungi . Eventually, it’s possible that fungal communities — or enzymes from fungal communities — could pave the way for many different …
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Improving the Cacao Genome and Phytozome
… Global chocolate brands can’t exist without cocoa According to the  International Cocoa Organization (ICCO), global cocoa bean … plant is under threat due to climate change and devastating fungal infections. That’s why Mars, Inc., a maker of … genomics in support of DOE missions related to clean energy generation and environmental characterization and cleanup. …
Learn more
Mining Metagenomes for Cas Proteins
… Cas14 proteins discovered from JGI’s IMG/M database and biochemically … The ability to accurately edit genomes (that is, repair gene mutations, and either delete or add genes in a precise fashion) has applications across many … The work conducted by the US Department of Energy Joint Genome Institute, a DOE Office of Science User Facility, …
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