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Boosting Small Molecule Production in Super “Soup”
… still work in cell-free environments? (Spoiler: Yes.) Think of cells as tiny factories: within their walls they have … authors. “But this has been done most commonly in bacterial-based systems, and so one of the things that I think is so … for the past year and a half, “the logistics haven’t changed,” noted Northwestern graduate student Blake Rasor. …
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JGI@25 RECAP: 2022 Annual Meeting features historical perspectives on JGI’s 25 years
… As part of the JGI’s 25th anniversary celebration, the 2022 Annual … sequencing for the Human Genome Project out to the future of the institution. Their talks shed light on how the JGI … the Department of Energy (DOE) colleagues. “At that time (1986) 98% of the human genome was thought to be junk DNA, so …
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Designer DNA: JGI Helps Users Blaze New Biosynthetic Pathways
… A special issue of Synthetic Biology celebrates research enabled by the JGI … ways of controlling the pathway enzymes, and thus evaluate changes to the pathway more quickly.  The JGI has also … A third story from the issue — Machine learning-based prediction of activity and substrate specificity for …
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Boosting Small Molecule Production in Super “Soup”
… Yeast strains engineered for the biochemical conversion of glucose to value-added products are limited in chemical … authors. “But this has been done most commonly in bacterial-based systems, and so one of the things that I think is so … for the past year and a half, “the logistics haven’t changed,” noted Northwestern graduate student Blake Rasor. …
Learn more
Simon Roux Named 2025 ASM Microbiome Data Prize Awardee
… Congratulations to US Department of Energy (DOE) Joint Genome Institute (JGI) staff scientist … and impactful analysis of microbiome data that has changed our understanding of the microbiome and the … and functionally explore viral genetic diversity.  In 2021, he was among those selected by the DOE Office of Science …
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Exploring Possibilities: 2022 JGI-UC Merced Interns
… And also specifically, it sparked my interest in bioformatics, so that’s what I’m gonna take with me to the … are a little bit stronger in computing, so I was kind of worried coming into the, the internship that maybe I didn’t have as good of skills as somebody else might have. But Robert, uh, Bob …
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JGI Hosts GPU Hackathon in May
… JGI With DOE investments in graphical processing unit (GPU)-based high-performance computing resources, an upcoming … Computing Facility (OLCF), NVIDIA, and the Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office … aren’t getting any smaller and we need to keep pace with changes in industry/DOE Advanced Scientific Computing …
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JGI Pitches 2022 Visiting Faculty Program Collaborations
…   On November 3, 2021, the JGI and the Workforce Development & Education department of Lawrence Berkeley National Laboratory (Berkeley Lab) … Elisha Wood-Charlson for the DOE Systems Biology Knowledgebase (KBase) Ian Blaby for the JGI DNA Synthesis Platform …
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Refining the Process of Identifying Algae Biotechnology Candidates
… well ] The Science The recipe for growing algae as a source of sustainable biofuels seems fairly simple: place these algae in a container … feedstocks, algae are tiny but mighty. An analysis in the 2017 Bioeconomy Report estimated that the United States has … This research was supported by the Bioenergy Technology Office (BETO) within the Department of Energy’s Office of …
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Marchantia Pangenome Highlights Adaptive Nature of Plant Lineages
… Understanding the shared genetic toolkit of ancestral and present-day plants The Science In a recent  … paper , researchers focused on the full composition of genes, or pangenome, of the model plant  Marchantia … and environmental interests.  Summary As the planet has changed, so have plants. Curious about their ability to …
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Notes on the Microbial Diversity of Puerto Nuevo’s Coastline
… UC Merced graduate student Sabah Ul-Hasan and alumnus of the JGI-UC Merced Genomics Internship Program, first sampled the area in summer 2016.  She described the microbial diversity patterns of Puerto Nuevo’s coastal waters and sediment with …
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Better Genome Editing for Bioenergy
… A team has optimized a crucial part of CRISPR-Cas9 technology to enable improvements in … tool will make the right cut, researchers created a set of guide RNAs that were effective against 94 percent of the … genes were essential to  Y. lipolytica . They identified 1,377, or 17.5 percent, of  Y. lipolytica ’s genes to be …
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