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… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the … marine natural product biosynthesis and at the beginning stages of connecting molecules and genes. And then genomics … would spend time between our two laboratories doing metagenomics, some genomics. We were a little concerned …

… methods in the past decade, researchers have uncovered genomes for just a small fraction of Earth’s microbial … and the  DOE Systems Biology Knowledgebase (KBase) . Metagenomics is the study of the microbial communities in the … sequencing and analysis. “Using a technique called metagenome binning, we were able to reconstruct thousands of …

… The mission of the Joint Genome Institute is to serve the scientific community as a … and readiness to begin work, checking such factors as genome size, polymorphism level, sample quality and …

… analyses, such as metabolic modeling, that go well beyond genome annotation and analysis. The JGI and KBase seek to … data on scales ranging from single genes and individual genomes to metagenomes to systems-level modeling and understanding. JGI …

… Breaking Bad, I guess. But no, you trained me in how to genome mine, so thank you for that. And you had to put up … mentor students, teaching classes, and really setting the stage for what I really wanted to do and getting to– so I … rest of the archaea and fungal genomes and then work on metagenomes. So yeah. So we’ve taken every public sequence …

… lysogeny, they can insinuate themselves inside the host’s genome, living quietly and replicating with their host … a more systematic picture through single-cell and metagenomic sequencing. A team co-led by Mária Džunková, … the virus in 34 hosts or 26 percent of the single cells. Metagenomics sequencing then allowed the team to ask, for the …

… accessible, AI-ready large-scale data repositories for genome information with analysis tools for mining and … Science Program, the JGI sequenced and characterized 270 genomes of the Clostridium genus for LanzaTech, information …

… almost never Actinomycetes. And so when we look at their genomes we don’t get the same kind of information that we … they always cluster or could the genes be separated on a genome?  Dan: Oh yeah. It’s biology so anything is possible … That is one of the really big frontiers for the next stage of natural product drug discovery I think. Or even …

… of polyploidy and perenniality. The Science A reference genome sequence and genomic toolkit for the perennial grass … Miscanthus sinensis has been published. Analysis of the genome sequence also provides insights into how the multiple … environments such as poor soils and drought. The reference genome for M. sinensis, and the associated genomic tools, …

… Menaka Wilhelm, who is the host of JGI’s other podcast, Genome Insider . If you’re a Genome Insider listener, then … a mixture of, for example, metatranscriptome sequencing, metagenomics, single cell genomics. We even do the flow … for you, we sequenced thousands for you or thousands metagenomes. And I think also the quality that we provide. So …

… As an Integrative Genome Science User Facility, the JGI plays a leadership role in providing genome science capabilities to support BER's mission of … the boundaries of the Plant, Fungal, Algal, Microbial, Metagenome, Metabolomics, Secondary Metabolites, and DNA …