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… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … about his move to microbiology, about drug discovery and why it’s so hard to succeed, and we talk about an ongoing … bring it into the lab. And I think that criterion explains why the natural products in the ocean weren’t studied up …

… and the 90s. And so we started to be able to explore DNA sequencing and actually get to the DNA sequence – sequences … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less … We have a lot more data. Obviously, there’s been a lot of sequencing going on, especially at the JGI and in other …

… your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … JGI and this was before they were integrated. So I thought, why not feed it in there. And I went to group meeting and … AARON PURI: Yeah. No, you’re exactly right. So you can see why these are tightly regulated. DAN: For sure. For sure. …

… methods for efficient QA/QC based on next-generation sequencing technologies including PacBio and Illumina.  The …

… manager may then schedule and allocate resources for DNA sequencing. … No. However, the JGI does maintain a list of … … Guidance on international shipments can be found in the Sequencing Sample Overview file in our HERE (TK) .  Note: … appropriate alternatives. See specific protocols within the Sequencing Sample Overview file in our Documents Center, and …

NIGEL MOUNCEY: Oh, sure. I think our legacy obviously is in sequencing.  DAN: Of course.  NIGEL MOUNCEY: Sequencing the wazoo out of anything that’s relevant to the … so it’s really functional genomics. And there’s a lot of sequencing based approaches, of course, now that we can use …

… before– or kind of around about when the first genome sequencing was done. But natural products– marine natural … Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … around in natural products for a lot longer than genome sequencing, when we do a mass spec– a mass spec is like a …

Apple Podcasts or wherever you’re getting this and tell me why you’re listening. DAN: But, now, here’s Natural Prodcast … by the National Institutes of Health. DAN:  All right, why don’t you tell us a little bit about that. ROGER:  Yeah, … us, we want to hear from you! We have projects in genome sequencing, DNA synthesis, transcriptomics, metabolomics, …

… and viruses vastly outnumber the microbes. Advances in sequencing technologies and computational tools have … in collecting and submitting their microbiome samples for sequencing at the JGI cannot be overstated. Their … to defend against RNA,” Roux noted, “although it’s unclear why this is so rarely detected.” Developing Approaches for …

… contact us in advance for advice. … For accepted proposals, sequencing, synthesis, metabolomics and analysis will be … Energy’s funding of the JGI. … No, the proposal is only for sequencing, metabolomics and/or synthesis effort at the JGI. … in your proposal. … While, in general, requests will be for sequencing and its analysis, investigators are encouraged to …

We have developed Regulon Identification by in vitro-sequencing (RIViT-seq) to identify RNA polymerase-sigma … We are also utilizing DNA-Affinity Purification (DAP) sequencing to express hundreds of transcription factors and …

… things, because a lot of what we do at JGI in terms of the sequencing that we do is very people-disconnected, and … methicillin-resistant Staphylococcus aureus . Can you share why finding treatments for these microbes is so important? … to understand more about plant natural products? We have sequencing facilities, DNA synthesis, metabolomics. Where do …