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Structure determination of the HgcAB complex using metagenome sequence data: insights into microbial mercury methylation
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Programs & Platform Leads
… the boundaries of the Plant, Fungal, Algal, Microbial, Metagenome, Metabolomics, Secondary Metabolites, and DNA Synthesis Science Programs and draw from the infrastructure of Genomic Technologies and Data Science & Informatics. The JGI also sustains a vibrant …
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Mission
… provides advanced genomic capabilities, large-scale data and professional expertise to support the global … in doing so enabled the JGI to be the first to publish the sequence analysis of the target chromosomes 5, 16, and 19, … earth, and environmental systems for energy and infrastructure security. The BER research program seeks to …
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Doubling Down on Known Protein Families
Using a novel computational approach, researchers confirm … to better understand microbial communities by looking at protein function within them. The work was led by a team of … families known up until now, and identified many novel structure predictions,” said lead author on the paper …
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Natural Prodcast Episode 4: Nancy Keller
… they’re complex, they have different tissues, different structures, different spores. I like looking at that I’m a … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … Trying to even express a Cryptosporidium gene and get a protein product. It’s a very challenging organism to work …
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Synthesis
… capabilities support researchers exploring how to convert sequence into functional assessments. This is done by … Synthetic Biology Informatics Group : a team that develops data science tools for workflow management and novel … design tool  … BOOST provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination …
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Project Management Office
… of samples for sequencing, or the submission of sequencing data for synthesis – the DOE requires that all work …
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Synthetic Biology Lab
… the broader community.  We focus our efforts on integrating database mining and sequence design with scaling the production of large, … interested in:  characterizing novel enzymatic activities using phylogenomic driven approaches, and understanding the …
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Natural Prodcast Episode 5: Brad Moore
… or a seaweed, were just having just remarkable chemical structures and things that people hadn’t seen. For every … you use that to do? Brad: Yeah, absolutely. You know, we’re using it as a way to be able to better predict when a toxic … the end of last year. Dan: So these are going to be seaweed metagenomes? You’re sequencing everything? Brad: Metagenomes …
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The Surprising Structure of a Shrub Willow Sex Chromosome
… been sequenced with sufficient resolution to analyze their structure. Scientists found both a gene likely important for sex determination and a shared genetic architecture with Y … the shrub willows through the  Community Science Program , using long-read sequencing to assemble the repetitive areas …
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Partnerships: Myco-Ed
… and distribution of fungal genome datasets. It includes JGI-sequenced and publicly available datasets encompassing a … that no programming knowledge or dedicated compute infrastructure is required to perform computational analyses. The … can analyze their own data alongside public data, using a variety of open-source bioinformatics apps and …
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CSP New Investigator Call
FICUS proposal.   Competitive projects will provide pilot data to assess feasibility of a novel approach or form the foundation for a large-scale CSP proposal submission. Sequence requests should not exceed 3 Tb in total. Proposals … for scientific merit, DOE mission relevance , proposed data usage by the applicant/community, and track record of …
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