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Large-scale comparative analysis leads to identification of biosynthetic gene clusters for novel secondary … computational methods in the past decade, researchers have uncovered genomes for just a small fraction of Earth’s microbial diversity. Because most microbes cannot be cultivated under …

… is not exclusively for Euryarchaeota. Atmospheric levels of methane, a potent greenhouse gas, regulate Earth’s … Most methane is produced in environments without oxygen through a process called methanogenesis. Methanogenic … hot springs, an extreme environment with low genetic diversity that would help narrow down potential sources of …

… … DAN: You’re listening to the US. .Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … up a great body of work, with interesting perspectives on evolution of natural products biosynthesis. I think it will … similar to like human crops like corn. There’s low genetic diversity in the crop. So they’re susceptible to disease. …

In late June, Kathleen Lail, a member of JGI’s Sample Management Group, attended a conference in … They chose this location because much is unknown about the diversity of organisms (taxonomy) and particularly those in … and organic carbon concentration. From Field Studies to Publication Together as a class, the students learned about …

… while, but Natural Prodcast is back again for another round of episodes. If you stick around for the next few months, … proposals that are really multifaceted, that do request a diversity of the different capabilities that we have, that … do the bioinformatics and to synthesize these results into publication? So there’s this really important because we …

Below is a brief description of the process needed to prepare and ship samples for … sample QC requirements and protocols Obtaining DNA and RNA of suitable quantity and quality has been the rate-limiting … project manager will keep you updated as your samples move through QC and into the library and sequencing pipelines. …

The mission of the Joint Genome Institute is to serve the scientific … scientific discovery at the DOE Office of Science through high performance computing (HPC) and data analysis.  … more customized analysis, the JGI also participates in publication of results. … Submission … More on Sequencing …

… (Trillions) Operating Hours Goal Actual Total* Actual % of Goal Goal (hours)** Actual Total Actual % Goal FY 2025 … platforms. **Operating Hours target is based on 98% of the total available hours.   FY 2024 DOE Metrics There … (Trillions) Operating Hours Goal Actual Total* Actual % of Goal Goal (hours)** Actual Total Actual % Goal FY 2024 …

Celebrating 25 years of genomics research 2022 marked the JGI’s 25th anniversary. We revisited a number of notable achievements that showcase our collaborations and … the JGI’s 25th anniversary, the JGI mural references dozens of iconic JGI contributions to advancing the frontiers of …

… automations for DNA design, assembly and analysis Overview of synthesis products The JGI DNA Synthesis platform enables … CRISPR gRNA design tool  … BOOST provides a suite of tools to automate sequence design for assembly by Gibson, … … Plus: SynTrack and associated tools, which track samples through the JGI’s Synthetic Biology pipeline as well as …

… cohesive data standards, the JGI partners with a number of facilities.  … Through its partnership with NERSC and the DOE Energy … to facilitate these efforts. Particular areas of emphasis will be the development of tools and …

Welcome back to Natural Prodcast. This continues the series of interviews we recorded at the Society for Industrial … made it onto our list is because we wanted to have diversity. And so we wanted a profile across that protein … AU.  2023.   doi: 10.1021/jacsau.3c00263 “Deciphering the evolution of flavin-dependent monooxygenase …