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… will bind to receptors within biosynthetic gene clusters. Specifically, these are Tet repressors that oftentimes turn … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain … we've actually found a decent number with decent antibiotic activity. We haven't found any with anti cancer, but it is …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … and the 90s. And so we started to be able to explore DNA sequencing and actually get to the DNA sequence – sequences … systems are also everywhere – that there are some very specific patterns and shared DNA across all of these things. …

… Celebrating 25 years of genomics research 2022 marked the JGI’s 25th anniversary. We revisited a number of notable achievements that showcase our collaborations and … the JGI’s 25th anniversary, the JGI mural references dozens of iconic JGI contributions to advancing the frontiers of …

… Outreach at JGI takes many forms: We offer internship opportunities through working directly with specific universities, continuing education programs in the … Overall, our aim is to inspire students and established professionals to explore opportunities in STEM by providing …

… have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a … was that it was one of the first genomes that had been done specifically in order to explore its secondary metabolism, … And I think a lot of times, too, when we even look at publications, it’s always positive data, right? No one ever …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … dozens of them. Some are going to be involved in antibiotic activity, some are going to be involved in signaling. We’re … actually been due to antibiotic use in agriculture. Well, specifically raising animals and, so, like a prophylactic …

… you may have hear over there, with a few more questions specific to secondary metabolites. I hope both versions are … Science program. It used to actually stand for Community Sequencing Program. Also CSP, same acronym. But as JGI, as a … do the bioinformatics and to synthesize these results into publication? So there’s this really important because we …

… functional genome annotation, improves understanding of the role small molecules play in diverse biological … sheds light on nutrient cycling, and leads to the discovery of new molecules and pathways. The JGI Metabolomics Platform … are identified using LC-MS/MS methods optimized for specific types of molecules.   …

… which was a very early genome mining company, back when DNA sequencing of natural product pathways was hard and … different approaches. Some of them have been actinomycete-specific approaches. And you can enrich for rare … into well plates. And we can use our fancy multiplexed activity metabolomics method to tell us what’s active, which …

… for you here today. We got the opportunity to talk to one of the real legends of natural products, Professor Bill … the cells to divide. We found all sorts of molecules with specific targets. Did we know how to find those? Not at all. … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… develop computational approaches to sift through thousands of metagenomes for signatures of viruses and novel microbial lineages, and reconstruct … and viral diversity, leading to a better understanding of microbial communities and ecosystem function.  The … Our research focuses on the assembly of metagenomic sequence data into microbial genomes, which is of …