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… products is that we don’t know what all the biosynthetic gene clusters look like.  DAN: For sure.  MARCY: We have so … much information about what the Actinomycete biosynthetic gene clusters look like. And we’re just getting to where … finding the molecules so then we can tie them back to the gene clusters right? The more Info we have the more Info we …

… After I got my undergraduate degree, which was in general biology, I joined the Peace Corps. And when I was … looking at that I’m a very visual person. So, when we make genetic mutants in a fungal isolate, I can see something … Yeah, okay. Of course. Fungi have a larger genome. The genetics was slower to begin with. So transformation, or …

… that can’t live without their host. They have no extra genes hanging around, they still dedicate 20-30% of their … of many different things in microbiology and biology in general. And her efforts first at Yale and now at University … with JGI to do genome sequencing, so to look for the genes that are involved in putting antibiotics together, …

… and actually get to the DNA sequence – sequences for the genes that code for the proteins that produce secondary … developed to the point that you could understand the genetics of secondary metabolism, it became possible to do … proteins that are enzymes that are doing the reactions to generate secondary metabolites. ALISON: Sounds easy enough? …

… include exploration of the global diversity of alternative genetic codes (Science 2014), unearthing hundreds of … Science 2017, Nature Microbiology 2018), discovery of new genes with important biotechnological applications (e.g., … Camargo AP. et al. (2023) Identification of mobile genetic elements with geNomad. Nat Biotechnol . Epub. Neri …

… critical requirements for amplifying the JGI’s impact. Data generated from a single investment will be reused for … host taxonomy, conjugation potential, antibiotic resistance genes, and ecosystem information. … available sequenced algal genomes and genome annotations generated by the JGI and by others. The web portal allows …

… I was imagining some massive contraption for amplifying genes. I wasn’t really sure what actinobacteria were. Dan … to you, but they’re unprecedented in the terms biosynthetic gene clusters and genome size. And they’re so complex. … produce, their ability to evolve, to go with horizontal gene transfer and run with it and produce different …