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… still work in cell-free environments? (Spoiler: Yes.) Think of cells as tiny factories: within their walls they have … , researchers led by Hal Alper at The University of Texas at Austin and Michael Jewett of Northwestern … environment, which would be transformative at industrial scales. “Cell-free systems have been really powerful at …

… The Science Researchers have successfully automated aspects of a commonly-used process for studying microbial … with results published in the  November 2022 issue of Microbiome . High-throughput stable isotope probing (SIP) … microwell plates, allowing them to be processed at a larger scale through downstream DNA purification and sequencing …

… Yeast strains engineered for the biochemical conversion of glucose to value-added products are limited in chemical … an alternative format for chemical synthesis in the absence of cell growth by isolating the soluble components of lysed … environment, which would be transformative at industrial scales. “Cell-free systems have been really powerful at …

… to global oceans. Through the Community Science Program of the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science user facility, 24 large-scale proposals have been accepted from 70 full submissions … The U.S. Department of Energy Joint Genome Institute, a DOE Office of Science …

… before. In 2006, the JGI produced 33 billion base pairs of sequence; by 2023, that number was almost 717 trillion. Last year, the JGI surpassed three Petabases of data sequenced — that’s three-quadrillion base pairs of … effort. For example, with support from the  Exascale Computing Project , the JGI — along with the National …

… ( CRAGE ). CRAGE enables scientists to insert large pieces of DNA (up to 60 kb) in a single step, directly into the genome. “CRAGE is central to our ability to offer host-engineering for our users,” says JGI Director … assess CRAGE’s impact, including how this application could scale,” says Mouncey. The JGI team has already demonstrated …

… in sequences affect traits. In a text file, the rows of letters A, T, C and G appearing over and over in a dizzying array of combinations, are unremarkable, save perhaps for the … capability; no one else can do it in the world at this scale.” A bottleneck in the DAP-seq protocol, however, is …

… A new view into a symbiosis could offer benefits to address climate change: pulling atmospheric carbon into soil and boosting biofuel feedstocks with less fertilizer. For millions of … In order to do so, these organisms share space at cellular scale: fungi stretch a network of tendrils called arbuscules …

… JGI interests in algae and secondary metabolites. A total of 27 proposals have been  approved through the annual  Community Science Program (CSP) call of the U.S. Department of Energy (DOE) Joint Genome … while also highlighting collaborative research of a scale exceeding a single lab’s capacity. Additionally, the …

… the fourth Director in its 27-year history. He has a wealth of managerial experience from almost 20 years in the … focused on the discovery, development and commercialization of novel production organisms and fermentation processes for … on secondary metabolites. He is also on the Leadership Team of the National Microbiome Data Collaborative and served as …

… Joint Genome Institute and has focused on applying state-of-the-art molecular methods to address wide-ranging … Scientist at Lawrence Berkeley Laboratory, and Adjunct Professor at UC Berkeley. Dr. Pennacchio received his Ph.D in 1998 from the Department of Genetics at Stanford University where he uncovered the …

… Nov. 2: Getting Credit for Scientific Contributions of Any Size What is considered to be a scientific … students (and their mentors) how to begin establishing a professional presence through getting credit for any scientific contribution they make, whether as part of a course or internship, and before ever publishing a …