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CRAGE-CRISPR combo helps further demystify biosynthetic gene clusters.  The Science Microbial secondary metabolites, … is a technique researchers can use to integrate large genetic payloads directly into diverse microbes. Combining … with a powerful addition to their toolkit to study gene function. As a demonstration, the researchers used …

… up associating transcription factors with their target genes. The Science Regulons are a group of genes that can be turned on or off by the same regulatory … regulation as well as identification of target genes of transcription factors, particularly sigma factors …

… viruses. Almost all known virophage genomes share only four genes in common: major and minor capsid proteins (MCP and … includes  IMG/VR (for Virus)—for the virophage marker gene MCP, they were able to identify 44,221 total virophage … diverse new virophage genomes containing all four core genes. These virophages were found in diverse habitats …

… de Crécy-Lagard on using comparative genomics to predict gene function in bacteria and leveraging molecular biology and reverse genetics to test those hypotheses. From 2011 – 2015, she … Blaby-Haas CE, Merchant SS. (2021) Widespread polycistronic gene expression in green algae. PNAS  118 (7) e2017714118 …

… to determine the genome structure of SAR324 cells and their gene expression, the team then sequenced community genomes and expressed gene transcripts (metagenomes, metatranscriptomes), as well … the team unprecedented resolution to study the network of genes that contribute to the metabolisms that individual …

… interaction up close, using RNA sequencing to understand gene expression: one of the first cross-kingdom … can serve as a reservoir for carbon compounds that plants generate from carbon dioxide they take in. In this way, … with fungi, they used multiple approaches to look at gene expression in both plant cells and fungal cells. Using …

… novel clades of RNA viruses and determines novel viral gene functions that may impact hosts and host populations. …

Marcel is in charge of several production pipelines (gene calling, functional annotation and methylomics) that …

… methanogenic archaea use one of three pathways for methanogenesis: hydrogen-dependent and CO2-reducing, or … and, acetoclastic. All three pathways require the gene cluster for methane production known as Mcr. Until recently, the Mcr gene cluster was found only in the archaeal lineage …

… into functional assessments. This is done by synthesizing genes, pathways, and whole chromosomes for bioenergy, … DNA Synthesis platform enables users to validate hypotheses generated from mining genomic data by designing and …

… known up until now, and identified many novel structure predictions,” said lead author on the paper Georgios … sequencing allows researchers to study the entire genetic makeup of these communities via whole genome … Division,” Pavlopoulos said. “They developed parallel algorithms to perform ‘all-vs-all’ comparisons and graph …