Search

… Udwary: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a podcast about natural … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … sometimes correlated or anti correlated, also with other cellular functions in the same and as it was other bacteria …

… quantities of DNA derived from individual environmental cells. The proof of principle study built off earlier … year, the JGI team reported the first closed and finished genome derived from an uncultured bacterial single cell – a symbiont of the green sharpshooter. In 2012, …

… that – I want to say like lipid bilayer, you know, in the cell.  DAN: It depends on lifestyle. So there are lots of … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … think of bacteria. You think of bacteria as sort of these single celled organisms, kind of all over. But these kinds …

… and predictive biology, modeling and biodesign — questions of relevance to DOE’s Biological and Environmental Research … While applications will be accepted that address any aspect of these mission areas, priority will be given to projects … and track record of the applicant. For accepted proposals, sequencing, synthesis, metabolomics and analysis will be …

… initiatives new to the JGI. Projects must be independent of ongoing JGI proposals, and lead PIs cannot have been lead … projects will provide pilot data to assess feasibility of a novel approach or form the foundation for a large-scale … an unlimited number of proposals).  For accepted proposals, sequencing, synthesis, metabolomics and analysis will be …

… it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk … parasite you really can’t grow well. You have to have it in cell culture. So we are going to see if we can express that … alone – I’m interested in pathogens. It’s just never a single microbe. And we have several recent papers and are …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … we want a chemist to study the ocean. And I didn’t find a single job advertisement. But one day, I decided to really … that the molecules out there would be toxic to cancer cells. And that started something big. Because at that time, …

… predict or just understand better the language of microbial cell-cell communication. And he told us about his work in … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … and they were able to synthesize the genes for every single one of those and put them in individual plasmids and …

… be successful. Right? Because we don’t – drugs are usually single molecules, they are not extracts. And so yeah, in … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less … in ourselves and every living thing that we know of with cells, and so… So you can think of DNA as maybe being …

… For accepted proposals, sequencing, synthesis, metabolomics and analysis will be paid for by the Department of Energy’s funding of the JGI. There is no cost to the user … with DOE mission-relevant projects that call for expansive sequencing, synthetic biology, and metabolomics capabilities …

… The Genome Insider podcast brings listeners into the science … — JGI Users — and dives into their work on all kinds of organisms, from plants and fungi to microbes and viruses. …