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… And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … thousand fully sequenced biosynthetic gene clusters from organisms that had not been previously evaluated. So we … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, …

… out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk … see how that goes.    ALISON: Is this the only class of organisms that makes this polyketide structure that we’re …

… The JGI is leveraging its current partnerships to offer new capabilities and resources to users through a BER … to diverse datasets that deepen our understanding of how organisms interact with each other and with their … (ESNet), the JGI has unique access to both expertise and infrastructure to facilitate these efforts. Particular areas …

… to play with that a little bit. JACKIE: So I guess the organisms you're working with, to see how they respond, … The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain …

… able to explore DNA sequencing and actually get to the DNA sequence – sequences for the genes that code for the … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less … time to get to the point of being able to sequence whole organisms, but eventually we got there. But before that …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … Do you want to touch a little bit on that? What are these organisms? AARON PURI: Yeah. Sure. So when we say a …

… Facility, the JGI serves more than 2,500 users that predominately come from the public sector: academic and government institutions — with capabilities that had remained largely … joined the JGI in 2017, he brought with him 20 years of industry experience — and an opportunity to expand the …

… The Genome Insider podcast brings listeners into the science that the … — JGI Users — and dives into their work on all kinds of organisms, from plants and fungi to microbes and viruses. …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … program. Like how – is like Jo just the ambassador of microorganisms in soil and – MARC: That is a perfect way to put …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … a really helpful way of, for example, finding out which organisms, for example, are likely for which organisms, …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … of survival by providing deterrence and rendering some organisms just simply unpalatable. And we know that this is … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …