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… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … was looking to develop new methods for DNA sequencing of microbes. And what kept breaking our methods was these damn … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very …

… You can visit the Products & Offerings section of our website for more details, including a downloadable pdf of products categorized by Science Program.  … The majority of JGI projects come from the user community. Find out about … proposal calls and proposal submission, as well as examples of approved proposals, please visit the Proposals FAQ .  …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … ecology community to be able to better predict how their microbes are interacting with each other from sequence …

… we really recognize, right?  ALISON: And I tend to think of microbes as being able to secrete a lot more things than … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

… systems. No one was, at that time, really working with microbes from the ocean. So I felt there was a wonderful … then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against …

… Secondary Metabolites Program focuses on the exploration of secondary metabolites across bacteria, fungi, algae and … for fundamental growth, provide critical advantages to the organisms producing them, and are often involved in … compounds are biosynthesized and their roles in the environment, can unlock new avenues for bio-based products and …

… Populations of Antarctic lake microbial communities change with the seasons. The Science Light-harvesting bacteria (phototrophs) in Antarctica’s Ace Lake defy the norm when it comes to nutrient cycling in polar regions. While microbial populations in … (project 4031). The work conducted by the US Department of Energy Joint Genome Institute, a DOE Office of Science …

… Celebrating 25 years of genomics research 2022 marked the JGI’s 25th anniversary. … that showcase our collaborations and capabilities to enable great science that will help solve energy and environmental challenges.  Commissioned for the JGI’s 25th … Notable Stories …

… A deep dive into microbial genomics reveals one bacterial species is made … In the ocean’s North Pacific Subtropical Gyre, microbes tend to stay localized at different depths. But … of SAR324 cells and their gene expression, the team then sequenced community genomes and expressed gene transcripts …