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… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … ALISON: Hmm. It kind of – it’s kind of like I’m smelling bacterial perfume. I mean – but it’s purposeful so it’s some …

…   The U.S. Department of Energy (DOE) Joint Genome Institute (JGI) is a national … at Lawrence Berkeley National Laboratory. The JGI consists of around 280 researchers and support staff in the …

… out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk … Then you have to maybe improve some of your bioinformatic analysis. You don’t want to get clusters that are encoding …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… initiatives new to the JGI. Projects must be independent of ongoing JGI proposals, and lead PIs cannot have been lead … the foundation for a large-scale CSP proposal submission. Sequence requests should not exceed 3 Tb in total. Proposals … accepted proposals, sequencing, synthesis, metabolomics and analysis will be paid for by the Department of Energy’s …

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a … tool. It’s the best thing that we have. And its rule-based analysis is second to none. And it’s the most valuable thing …

… data portal allows anyone to freely investigate the genes of more than 100 algae. The Science Interested in the … algal genomes can be incredibly complex and difficult to sequence and understand. A team of researchers led by Algal … microbial and metagenome datasets, MycoCosm for comparative analysis of fungal genomes, and Phytozome for comparing …

… … DAN: Hello, everyone, and Welcome back for Episode 14 of Natural Prodcast . There’s been a lot going on, so I took … to some people more about down the road. Email Nigel! He’ll sequence whatever you want!  [LAUGHTER]  NIGEL MOUNCEY: We … has led a vision for the JGI that sees secondary metabolism analysis and research as a driver for novel technologies …

… here today, and we wanted to talk to her about a whole list of things. So we have a Scripps background shared together, … Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … pellets. So, we’re about ready to send those for genomic analysis. And of course, we don’t know anything about the … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… the JGI plays a leadership role in enabling the frontiers of research related to DOE’s missions in bioenergy, carbon … JGI researchers drive innovations that cross the boundaries of the Plant, Fungal, Algal, Microbial, Metagenome, Metabolomics, Secondary …