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… strengthens -omics technologies at the JGI by identifying the actual molecules present in an environment that …  Through this identification, metabolomics enables functional genome annotation, improves understanding of the role small molecules play in diverse biological …

… … Dan Udwary: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a … about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean …

… is also reflected in the strongly biased representation of sequenced genomes in the public domain, the bulk of which … cells are characterized and selected as based on a specific functional trait or phenotype of interest, prior to and in … Giant virus diversity and host interactions through global metagenomics.” Nature 578(7795): 432-436 (2020). Seshadri …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain …

Populations of Antarctic lake microbial communities change with the seasons. The Science Light-harvesting bacteria (phototrophs) in Antarctica’s Ace Lake defy the … to our larger understanding of carbon and other nutrient cycles on a global scale. Summary Ace Lake, located in the …

… for you here today. We got the opportunity to talk to one of the real legends of natural products, Professor Bill … learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… on DNA sequencing and synthetic biology. But also the metagenomics and gut microbiome, as I think that it’s like a … the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very …

Secondary Metabolites Program focuses on the exploration of secondary metabolites across bacteria, fungi, algae and … growth, provide critical advantages to the organisms producing them, and are often involved in defense, nutrient … computational analyses of BGC size and complexity, BGC sequence composition, metabolic similarity & compatibility, …

Christa Pennacchio   … You can visit the Products & Offerings section of our website for more details, including … ) The following tools are available for functional annotation/curation of your genomes Microbial … I request a culture/slant/DNA of an organism that has been sequenced at the JGI? … How do I check the current status of …

Large-scale comparative analysis leads to identification of biosynthetic gene clusters for novel secondary … Group. Many of these bacterial and archaeal genome sequences have been generated using techniques that the JGI has pioneered, including single-cell genomics and metagenomics. The GEBA initiative has also utilized a very …

Metagenome-assembled archaeal genomes provide new insights into an ancient metabolism. Methane is a greenhouse gas 20 times more potent than carbon dioxide. Billions of years ago, methane-producing archaea likely played a key …

… characteristics — creating many different ways of processing nitrogen. To boost crops more efficiently in … the JGI provided DNA synthesis capabilities to enable functional testing of these enzymes. Yasuo Yoshikuni, head … to the way many organisms function, they have a sense of why nitrogen metabolisms can be so varied.  As evolution has …