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… Research in the Woyke laboratory focuses on the utility of single-cell methods to access genetic material of uncultivated taxa of interest. One such effort is … is also reflected in the strongly biased representation of sequenced genomes in the public domain, the bulk of which …

… for you here today. We got the opportunity to talk to one of the real legends of natural products, Professor Bill … learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… Populations of Antarctic lake microbial communities change with the seasons. The Science Light-harvesting bacteria (phototrophs) in Antarctica’s Ace Lake defy the … to our larger understanding of carbon and other nutrient cycles on a global scale. Summary Ace Lake, located in the …

… on DNA sequencing and synthetic biology. But also the metagenomics and gut microbiome, as I think that it’s like a … the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very …

… Kerrie Barry or Vivian Ng Prokaryotic projects: Tijana Glavina del Rio , Danielle Graham , or Miranda Harmon-Smith DNA … You can visit the Products & Offerings section of our website for more details, including a … The majority of JGI projects come from the user community. Find out about …

… Secondary Metabolites Program focuses on the exploration of secondary metabolites across bacteria, fungi, algae and … growth, provide critical advantages to the organisms producing them, and are often involved in defense, nutrient acquisition and … Program targets the vast and underexplored reservoir of secondary metabolites produced by bacteria, fungi, algae …

… starts with a User Agreement — before any work can begin, including the submission of samples for sequencing, or the submission of sequencing data for synthesis. This agreement, required … After your proposal is approved, the Contracts Officer will send required paperwork to your …

… Metagenome-assembled archaeal genomes provide new insights into an ancient metabolism. Methane is a greenhouse gas 20 times more potent than carbon dioxide. Billions of years ago, methane-producing archaea likely played a key … The U.S. Department of Energy Joint Genome Institute, a DOE Office of Science …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… characteristics — creating many different ways of processing nitrogen. To boost crops more efficiently in … the JGI provided DNA synthesis capabilities to enable functional testing of these enzymes. Yasuo Yoshikuni, head … to the way many organisms function, they have a sense of why nitrogen metabolisms can be so varied.  As evolution has …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … the DNA that was breaking the sequencing from really being functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways …