Search

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … had to scale also by orders of magnitude. And that’s why Satria figured out some new clever tricks to make an …

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … that I never anticipated starting– that’s not why I came to the University of Utah– is looking at the … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

… And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … And that’s what I really wanted to do. And that’s why I came back to academia. And I set that up. And we …

… We focus our efforts on integrating database mining and sequence design with scaling the production of large, … developing methods for converting digital information from sequence databases into biotechnological or environmental …

… culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … that is often done, where we’re really just looking at DNA sequences, and we don’t always know necessarily or pay … methicillin-resistant Staphylococcus aureus . Can you share why finding treatments for these microbes is so important? …

… I request a culture/slant/DNA of an organism that has been sequenced at the JGI? …

… The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain … are capable of making those strange ring systems. JACKIE: Why? Is it just because of ring strain or is it-- I guess, …