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… and actually get to the DNA sequence – sequences for the genes that code for the proteins that produce secondary … developed to the point that you could understand the genetics of secondary metabolism, it became possible to do … we’ve got a picture up here of the erythromycin polyketide synthase.  DAN: And, so, you don’t need to know what all …

… rights in technical data, project reporting to the DOE, and publication requirements. An official with authority is …

… what we’re calling a Primer. We wanted to try and give a general audience some of the basics of natural products … knowledge of modern biology. We’re trying to keep this as general as possible, but scientists love technical jargon. … all over the place. So that smell of rain is just these terpene molecules that these bacteria produce and secrete …

… see as the overall “theme” of your research? I know you’ve generally worked in various marine organisms. Except during … really need to know how they’re made. You need to bring the genes into the lab, and you need to manipulate them in the … you’d like to read more about this, I highly recommend his publication last year, “The Biosynthetic Diversity of the …

… this gap, by tracing the evolution of a specific enzyme family called aminotransferases (ATs). These enzymes play a … This analysis led them to identify 2,938 putative AT  genes. Within the AT genes identified across different species, each organism has …

… oftentimes will bind to receptors within biosynthetic gene clusters. Specifically, these are Tet repressors that oftentimes turn off these biosynthetic gene clusters. And so we've been really interested in trying … interested in their connection to these biosynthetic gene clusters. DAN: OK. So maybe if we talk in a really …

… have a structure belonging to a group of chemicals called terpenes. Terpenes are important in plant growth, defense, … buck. The research team reports that transferring just four genes encoding these enzymes to another plant, such as  … the zealexin pathway utilizes dexterous enzymes— terpene synthases and cytochrome P450s — that catalyze multiple …

… conditions, with only a small portion of the biosynthetic gene clusters (BGCs) being expressed. The program works to … uncover these hidden biochemical resources by exploring the genetic pathways responsible for their synthesis. The … developing computational tools for predicting biosynthetic gene clusters (BGCs), advancing pathway analysis, …

… Project design with Principal Investigator Providing a general orientation to JGI systems to Investigators … access your data, share with collaborators, and coordinate publication with JGI scientists. Synthetic DNA constructs …

… America brought to the UK? ROGER:  Yeah, it’s difficult to generalize, of course, but I felt overall that the British … my perspective, JGI has a large database of biosynthetic gene clusters and biosynthetic gene cluster fragments, and … hypotheses, about the relationship between a compound or family of compounds and corresponding gene cluster or family …