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… culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … that is often done, where we’re really just looking at DNA sequences, and we don’t always know necessarily or pay … I think on COVID that we’re getting ready to submit for publication and have found some interesting hits for that as …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … lot of people would consider more straightforward chemical biology, a lot of which people classify as tool building. So … up on previous Natural Prodcast episodes  here . Show Notes Publication: Suo Z et al. A Mesorhizobium japonicum quorum …

… Undergraduate Research Experience (CURE) that consists of coordinated hands-on experiments across fungal biology teaching labs. The purpose of the program is to: train students and professors in … the Arizona Genomics Institute where high molecular weight DNA is extracted from samples, which is then sent to the JGI …

… analysis techniques to explore the vast and diverse world of microbes. Studying bacteria and archaea, including those … associated with microeukaryotes, enhances our understanding of terrestrial biogeochemical cycling and inter-organismal … microorganisms, by sequencing large populations of bacteria and archaea in their natural environments using …

… JGI Mission As a U.S. Department of Energy Office of Science user facility, we provide advanced genomic … and manufacturing. Genomic science lies at the heart of biology, providing the foundational knowledge to … systems.  Invasive plant species; and first-generation biofuel targets (i.e. corn, sugarcane, rapeseed/canola, palm …

… at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … in addition to sequencing, we offer metabolomics and also DNA synthesis. And we consider these capabilities a little … do the bioinformatics and to synthesize these results into publication? So there’s this really important because we …

… have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a … or whatever you’d like, whatever D– you can submit any DNA sequence really, and it will go through SMC’s pipeline. … And I think a lot of times, too, when we even look at publications, it’s always positive data, right? No one ever …

… Secondary Metabolites Program focuses on the exploration of secondary metabolites across bacteria, fungi, algae and … advantages to the organisms producing them, and are often involved in defense, nutrient acquisition and … their potential applications in the bioeconomy including biofuels, biochemicals and sustainable agriculture. …

… Research in the Woyke laboratory focuses on the utility of single-cell methods to access genetic material of uncultivated taxa of interest. One such effort is … Anomaly” first described by Stanley and Konopa in 1985, which highlights our skewed understanding of microbial …

… uses advanced sequencing technologies to decode the genomes of microbes in their natural environments. This work … drive innovations that could advance our understanding of Earth’s ecosystems. … functions that shape ecosystems. By decoding the microbial DNA in natural environments, the Program provides a snapshot …

… sponges, can you maybe explain what’s going on with their biology and why they’re so important to natural products? … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a … and so on that we can consult in designing pieces of DNA that we can use to test these issues. The second area …

… The Fungal & Algal Program explores the vast diversity of fungi and algae to unlock their potential for bioenergy, … and bioproducts. By sequencing and analyzing the genomes of these organisms, the program investigates the biological … into practical applications, including sustainable biofuels, biomaterials, natural products, and environmental …