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… Research in the Woyke laboratory focuses on the utility of single-cell methods to access genetic material of uncultivated taxa of interest. One such effort is targeted at environmental … in the strongly biased representation of sequenced genomes in the public domain, the bulk of which belong to …

… in the early 2000s called Ecopia, which was a very early genome mining company, back when DNA sequencing of natural … And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … called Ecopia was talking about a gene cluster a week. They completed a gene cluster per week. And that really got me …

… And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … almost never Actinomycetes. And so when we look at their genomes we don’t get the same kind of information that we … genome sequence, in about 40% of the genome the genes were completely unidentifiable. You had no idea what they were …

… The Joint Genome Institute and the Molecular Foundry have launched a … for researchers to request the capabilities and expertise of both national user facilities in one research proposal.  … challenges in the sourcing, recovery, and utilization of critical minerals and materials. The proposal submission …

… enzymes to do chemical reactions. Obviously, in my work, in genome mining, we have an awful lot of crossover, where us … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh … or something, but they confirmed that it had just been completely consumed. DAN UDWARY: Grad students need calories …

… Undergraduate Research Experience (CURE) that consists of coordinated hands-on experiments across fungal biology … genomic resources empower students through isolation and genome sequencing of new fungal species.  Students collect … Myco-Ed has:  ~50 lineages selected for sequencing 16 genomes released 20 members from 15 institutions 300+ …

… exposure to working with Streptomyces, learning more about genome mining, as well as isolation and a little bit of … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain … with known receptors, but we also have ones that are completely their own cluster. And so we're hypothesizing …

… global nutrient cycling, however they do so under strong constraints exerted by viruses. Research in the viral genomics … group aims at improving our collective understanding of ecological and evolutionary parameters driving virus:host … involves both experimental and computational exploration of uncultivated viral diversity, characterization of …

… Breaking Bad, I guess. But no, you trained me in how to genome mine, so thank you for that. And you had to put up … And I think a lot of times, too, when we even look at publications, it’s always positive data, right? No one ever … trying to understand that system is just not possible from– completely understanding the system is not possible from the …

… for researchers to request the capabilities and expertise of both the Joint Genome Institute and the Molecular Foundry in one research … provides customized analysis, the JGI also participates in publication of results. Go here for a video and Q&A with … as needed), and the work plan is written into a Statement of Work document. …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a … you’d like to read more about this, I highly recommend his publication last year, “The Biosynthetic Diversity of the …