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… antibiotics. Still, the team estimates that genomic information is only available for a fraction of extant … has also utilized a very large collection of type-strain isolates, provided by the Leibniz Institute DSMZ – German … than 3,400 genomes have been sequenced from curated DSMZ isolates, for which quality DNA has been provided by the …

… JACKIE WINTER: Yeah, I think we actually use some of your information from those days. As a grad student, I think I use … mining is not knowing if something is active before you isolate it, after isolating lots of things that were not … cell level against cell lines and against primary cells isolated from patients up to 12 markers at a time. And these …

… place, but you will not know they existed, up until you isolate the compound. But today, by genome sequencing, you … have to, as in the past, go randomly looking in places to isolate. And we can now specifically look in places [that … do it. You have the sequencing capacity, you have the bioinformatics, but also you have all the emerging technology …

… event of a new infection, the microbes use the genetic information encoded in CRISPR sequences to target the virus and release attack enzymes in the form of Cas enzymes to cut the DNA and disable the virus. In … UC Berkeley news release  Smallest life forms have smallest working CRISPR system …

… I ntegrated Microbial Genomes and Metagenomes, the IMG platform that JGI has that really got me into that because we … so the tundripaludum part there comes– the type strain was isolated from Svalbard Norway so right there by the Arctic … about that we put into antiSMASH after downloading it was isolated from Lake Washington. So it’s really interesting …

… on the ground and what escapes to the atmosphere in the form of greenhouse gases (e.g., carbon dioxide, methane, and … these distractions. Combining genome and transcriptome information allowed the team to have a much more comprehensive … from these habitats. The proteins in the samples were then isolated and sequenced by scientists at the Environmental …

… look like.  DAN: For sure.  MARCY: We have so much information about what the Actinomycete biosynthetic gene … the different genomes and also in the chemistry.  MARCY: We isolated Lincomycin from one of our squid bacteria and we … we have been working on for this is a Streptomyces that we isolated from a tunicate, does it work with the …

… have against pathogens from the clinic. At that point, isolates get shipped to us in Wisconsin, and we try and use … more than that of metabolomes. So 10,000. We have many more isolates right now than we’ve processed. So it’s an exercise … we wanted to test out in our paper, whether or not that conforms to mosaic theory. And in terms of how potent the …

… to!   DAN: No, I think your stuff was really important to forming my concepts of what – at least outside of working directly with Craig – but forming those concepts of what natural product studies look … visual person. So, when we make genetic mutants in a fungal isolate, I can see something right away, and that’s exciting …