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… of Utah in the Department of Chemistry. So welcome. DAN: How do we introduce Aaron? JACKIE: How would you like to be … could imagine if you have two colonies of bacteria in the soil or something and they’re competing with each other, if … ecology community to be able to better predict how their microbes are interacting with each other from sequence …

… is also twofold but for different reasons to learn about how nature builds molecules because nature does this with … ask questions about what don’t we know about this molecule. How do we discover more about what it can do, and as … them to making a compound, do you also take into account how are they going to behave in certain solvents or certain …

… listener, then you’ll recognize this material, though my show is a little more free-form, and this is the longer cut … where smaller proposals may be a fit. Still not 20 many microbes. We still we work in plates, right? We’re a high … that’s what we want to generate. Just to have the largest impact in the broader research community really. MENAKA …

… precursors into a bonanza of diverse structures. The Impact Zealexins belong to a class of chemicals called … many plants in addition to maize, including the bioenergy crop switchgrass. The team confirmed just how important zealexins are to maize health. Infections with …

… schedule and allocate resources for DNA sequencing. … No. However, the JGI does maintain a list of protocols, found in … be accessed via the Genome Portal , at the following sites: Microbes: IMG (citation: https://doi.org/10.1093/nar/gkaa939 … manager? … What types of products does the JGI offer? … How do I submit a proposal requesting sequencing, …

… fun conversation with Roger about all this, in terms of how to build an international community collaboration, and … it relates to structure elucidation and genome mining, and how we might start to better connect those two things, … now at  npatlas.org , and we’ll have links to it in the show notes at  naturalprodcast.com . DAN: I also just want to …

… ask the first question. Kate, can you tell me the story of how you got into secondary metabolites? Kate Duncan: So I … what’s important in terms of the chemistry produced by microbes. And by what’s important, I mean, like, where … data set, and then there’s how to access that and what impacts it in terms of the ecosystem and the environment. …

… for capturing the genetic make-up of specific uncultivated microbes from complex environmental samples. The Science A … to first target cells from communities of uncultivated microbes, and then efficiently retrieve and characterize their genomes. The Impact Despite great strides in generating genome sequences …

… biosynthetic pathway, and I’ll have to do a whole show on it one of these days. If you listen to the Nancy Keller interview , I think you’ll have heard how a lot of us who work in fungal natural products, especially in the old days, saw how hard it was – it felt kind of like training for a …

… including lignin, cellulose and hemicellulose. The Impact N. crassa is the model organism for filamentous … chemicals. Summary Filamentous fungi are like handymen who show up at a job site for a task that requires a flathead … sites of many transcription factors to better understand how nutrients are acquired and carbon is metabolized in …