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… a wide range of projects, from single-gene synthesis to the synthesis of entire chromosomes, advancing the … scientists to drive innovations that align with DOE's missions. … The DNA Synthesis Program plays a central … design-build transition in synthetic biology engineering workflows. … The IMG/M system serves as a community resource …

… for User Science (FICUS) initiative was established in 2014 to encourage and enable researchers to more easily integrate … increasingly collaborative and multidisciplinary nature of DOE mission science projects, this initiative aims to … who consider technical feasibility and readiness to begin work.  During scientific peer review, proposals are …

Dittmann, where I did my PhD later. And she happened to work with nature products from cyanobacteria. So that’s how … We had Brad on and he kind of waxed poetic about the early parts of the project. How did that postdoc where– I … outside my yard or so. Also, what we wanted to look at is, does it make a difference if I go today and tomorrow? Can I …

This summer, the DOE JGI hosted 10 interns who came from a wide range of … genomic data at a computer; a few had the opportunity to spend time out in the field, work at the lab bench, and also do some computational …

… provides the scientific community at large with access to high-throughput sequencing, synthesis, and metabolomics … the JGI for projects of relevance to Department of Energy (DOE)  Mission Areas . Through this program, the DOE aims to … proposal details with the PI and proposing team. The work plan is formalized in a Statement of Work document. At …

Alison Takemura, whose voice you’ll hear in a minute – we work for the US Department of Energy Joint Genome Institute, or JGI. JGI is a DOE Office of Science User Facility located at Lawrence … metabolism and secondary metabolism, and we talk about the early history of the field. Then, in the third episode, …

The mission of the Joint Genome Institute is to serve the scientific community as a user facility … ( NERSC ) is to accelerate scientific discovery at the DOE Office of Science through high performance computing … consider technical feasibility and readiness to begin work, checking such factors as genome size, polymorphism …

Brian went on to work at a groundbreaking company in the early 2000s called Ecopia, which was a very early genome … at naturalprodcast.com or through the JGI website at jgi.doe.gov . There’s a lot more to talk about there, and I’ll … Can we do total synthesis in vivo? And most of my career could be described as trying to do that and failing …

… user projects, the JGI’s Plant Program delves into the natural world’s potential to address global … to environmental changes. The program lays the groundwork for sustainable solutions to current problems facing … discussion with the JGI Plant Genome Advisory Committee and DOE, designating a set of JGI plant genomes that are the …

… recently started collaborating with Ben and his group to work on sequencing, synthesis and genome mining technology … cells. So, the very first compound was introduced in the early 90s and by using a polymer as a delivery mechanism. … What is beautiful for natural products is nature! Nature does this sort of – if you think of nature as a scientist, …

… a very long process. And then finally, if all of that still works, and you have a good target and a good drug, and … because we can find more things. Turns out some of the early genomes that were sequenced for, say, Streptomyces – … we recognize and sticking another piece in, that usually doesn’t work, or if it does work, it doesn’t work as well, …