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… processes with plants and animals, really, all over the world. We used ships. We used land-based marine labs. We … powerful people. These were people that really controlled microbial drug discovery. And a guy like me, with no … So, this was when we started saying, we have to have the genomes. We have to look at the full picture of these. And …

… and quality of finished product depend on genome. Selected genomes will be improved based on feasibility and scientific … physical separation of a biologically relevant unit from a microbial community, such as a microcolony, microbial aggregate, or a specific subset of free-living …

… went on to advance basic science by sequencing scores of microbial species as well as several model organisms and … as a national user facility, and has grown to serve a worldwide community of more than 2,000 primary users—those … processes relevant to DOE, and advance their utility across the bioeconomy. The BER  major objectives are to: …

… time now and almost ready for a real presentation to the world. … But, meanwhile, I’ve been sitting on all these … of thought with that. So some people are interested in cave microbial– people are interested in the more extreme … in the cave project just now switching from intermicrobial interactions, studying intermicrobial interactions …

… including fungal and bacterial symbionts, detrimental microbial pathogens, and associated viruses that all … how plants self-organize, influence, and are influenced by microbial partners. We use a variety of genomics-powered … to better understand the plant-associated terrestrial world. Research Team    … Plant microbiomes hold the amazing …

… pathways, which led her to a successfully funded JGI CSP project. And we also got to talk about work at her … outreach program to get kids interested in microbiology and microbial chemistry. All good stuff, and I hope you enjoy … in is actually seeing whether we could go into the genomes and predict what the natural product might actually …

… in Fort Collins have a massive undertaking: sequencing the world’s river microbiomes. And they’re using team science to …

… to try and create an open source database of all known microbial natural products. So if you think about natural … The information is scattered throughout literature. It’s across a huge array of different dates, journal titles, … had tremendous support from lots of researchers around the world. Europeans and North Americans, folks from South …

… about the field of biocatalysis and what needs to be done across science to to get a point where we can predict an … got you into natural products and got you excited about the world of natural products? ALISON NARAYAN: Oh where did it … group quite frequently. OK, so imagine this sentence comes across your desk. We’re developing this enzyme into a …

… organisms we’re finding– at least by looking at their full genomes — are really not like anything that’s been … has been doing work in secondary metabolism. The very first CSP I ever worked on back in Brad’s lab, we talked about it … are familiar with JGI’s IMG data portal , the Integrated Microbial Genomics, there was a subsection of that called …

… the secondary metabolism side of things was looking at genomes and seeing where the really hard things to sequence … Canada. I just got back from a conference in Canada on antimicrobial resistance sponsored by the Garner foundation. And … coming into the system. Now, that’s probably not true across all of nature, but it’s a simplifying assumption that …

… sponges. It’s an area – there’s some good groups around the world that focus on sponges. And so I feel like for the most … with the ribosomal peptide kind of natural product world is that those peptide products are much smaller than … products that are peptides are like the penicillins of the world, and vancomycins. They’re made via a “non-ribosomal” …