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… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … How can you design a drug, right? You design drugs  based on certain knowledge, without which, you know… If you … the natural product could be there. So this has really changed the paradigm of how to discover natural products. …

… Celebrating 25 years of genomics research 2022 marked the JGI’s 25th anniversary. We revisited a number of notable achievements that showcase our collaborations and … the Integrative Genomics Building was painted by Berkeley-based artist Nigel Sussman and dedicated at our 2022 Annual …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … to the market. And we get to say that six of those are based on natural product structures.  DAN: One of the things … knew you had a molecule. And you knew that if you made this change, which might be a small change, might be a big …

… Secondary Metabolites Program focuses on the exploration of secondary metabolites across bacteria, fungi, algae and … advantages to the organisms producing them, and are often involved in defense, nutrient acquisition and … roles in the environment, can unlock new avenues for bio-based products and bioenergy crop enhancement. The program …

… Research in the Woyke laboratory focuses on the utility of single-cell methods to access genetic material of uncultivated taxa of interest. One such effort is targeted at environmental … an era of ‘homology creep’, function prediction as purely based on annotation may not be sufficient. A more recent …

… . The Science A team led by researchers at the University of California, Berkeley used a multi-omics approach to … N. crassa is the model organism for filamentous fungi, all of which contain a wide array of plant cell-wall degrading enzymes (PCWDEs) that allow …