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… included researchers at the U.S. Department of Energy Joint Genome Institute (JGI), a DOE Office of Science User … a team of researchers sought to disrupt every gene in the genome with CRISPR-Cas9 in order to interrogate each one’s … a pool of sgRNA sequences: six for every gene in the genome. The JGI  DNA Synthesis Science team synthesized …

… was the last major crop without a reference quality genome and now crop researchers can work toward advancing … accounts for 80% of global sugar production. A reference genome for the sugarcane cultivar R570 has been  published … a crop. The Impact In providing a reference sugarcane  genome , the JGI provides foundational genetic information …

Describing the largest analysis to date of the modified DNA base 5mC variations in fungi. The Science Changing an A, C, T or G in a genome sequence can lead to changes in protein structures … 5mC is an important piece of how they regulate their genomes, but is not well understood in fungi. A team of …

Dr. Visel joined the DOE Joint Genome Institute in 2010. As the Deputy for Science … novel tools for large-scale in situ gene expression analysis in multicellular organisms. During his postdoctoral … for elucidating the gene regulatory landscape of vertebrate genomes, which led to the discovery of thousands of genetic …

Virophages are small viruses with double-stranded DNA genomes that co-infect eukaryotic cells along with giant … Virophages are small viruses with double-stranded DNA genomes that co-infect eukaryotic cells along with giant … including over 28,000 unique MCP sequences.  Further analysis led to the identification of 328 “high quality” …