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Extracting the Secrets of Secondary Metabolites
Repeats) is the leading tool for accurately editing genomes, its effectiveness has historically been limited due … edits affect functionality.  CRAGE allows for the transplanting of these BGCs from one organism into an alternate … applications for pest control and understanding how the pathogen uses insects for fuel.  The impact of the pairing …
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Uncovering Novel Genomes from Earth’s Microbiomes
Large-scale comparative analysis leads to identification of biosynthetic gene clusters for novel secondary … methods in the past decade, researchers have uncovered genomes for just a small fraction of Earth’s microbial … cannot be cultivated under laboratory conditions, their genomes can’t be sequenced using traditional approaches. …
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Ian Blaby
Joint Genome Institute, where he leads three groups focused on HTP DNA design and assembly, strain engineering and … Exploiting algal NADPH oxidase for biophotovoltaic energy. Plant biotechnology journal . 14: 1, 22-28. 2016 Blaby et. … responses and overlap with other stress transcriptomes. The Plant Journal . 84: 5, 974-988. 2015 Zones et. al., …
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A Redesign for Yeast’s Genome, Chromosome by Chromosome
To engineer yeast to do more, and understand genomes in general, Jef Boeke, Weimin Zhang (NYU Langone Health) and Leslie Mitchell (Neochromosome) have worked … to replace yeast’s native chromosomes with synthetic versions. This project has turned out to be an international …
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Microbial Genomics & Metagenomics (MGM) Workshop
Registration has closed.  The U.S. Department of Energy (DOE) Joint … Genome Institute (JGI) is offering a five-day workshop on Microbial Genomics and Metagenomics. Details: … designed to familiarize users with the Integrated Microbial Genomes & Microbiomes (IMG/M) data and workflows for …
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Fields of Breeders’ Dreams: A Team Effort Toward Targeted Crop Improvements
… recognize that crop varieties grow best in certain regions. Most plant species have adapted to their local environments; for … test genetic hypotheses in species with large and complex genomes,” said Lovell. “However, new sequencing technologies …
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JGI User Executive Committee Expands
… of Science User Facility located at Lawrence Berkeley National Laboratory (Berkeley Lab). They are: Ivan Baxter of the … Baxter is a principal investigator at the Donald Danforth Plant Science Center, where his group focuses on … decomposition. She’s also participated in the 1000 Fungal Genomes Project and has an interest in cross-disciplinary …
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How Filamentous Fungi Sense Food
… of California, Berkeley used a multi-omics approach to reconstruct and model gene regulatory pathways used by the … and decide on the order in which this fungus breaks down plant cell wall materials including lignin, cellulose and … enriching the work being done as part of the 1000 Fungal Genomes Project. Funding for the project was also provided …
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Tracing the Evolution of Shiitake Mushrooms
New genomes highlight the diversity of white rot fungi in the … genus Lentinula, which have evolved to decompose hardwoods on every continent besides Europe and Antarctica. A  new … and their evolution could provide strategies for converting plant waste into sugars for  biofuel production. …
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Doubling Down on Known Protein Families
Using a novel computational approach, researchers confirm microbial diversity is … through the publicly available  Integrated Microbial Genomes & Microbiomes (IMG/M) database, they successfully … has been no real analysis of protein families from metagenomes per se.”  Recently, other research teams have …
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Scaling Up Existing Skill Sets
… internship opportunities in fields ranging from plant-microbe interactions to functional genomics. Hear from five of the Summer … in Quantitative and Systems Biology Mentor: Guohong Wu, Plant Comparative Analysis What effect has your summer …
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Gut Fungi: Unexpected Source of Novel Chemicals
… and help them digest their last leafy meal. In their evolutionary history, these fungi branched off early from aerobic … called natural products . Yet, combing through the genomes of four anaerobic fungal species has revealed, for … compounds may also be involved in how the fungi metabolize plant biomass, which could inform how scientists can more …
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