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… that had in their genomes a surprising tool: a “diversity generating retroelement,” or DGR. The DGR could mutate the … to adapt to changing environments. It also sheds light on why the rapid injection of mutations in a particular gene … the dice. There’s some evidence to support the idea. Study coauthor Stephen Nayfach, a JGI bioinformatics …

… Jan. 7: New Capabilities to Study Secondary Metabolism   Although there are still a … often due to, for example, tight regulation of biosynthetic gene clusters (BGCs) in native hosts, the complexity of … expressing a given BGC in various hosts, availability of sequenced genomes, and computing resources needed to predict …

… The Science CRISPR-Cas9 is a powerful, high-throughput gene-editing tool that can help scientists engineer … Cas9 needs guide RNA to lead it to the correct sequence to snip — but not all guides are effective. To … I will spend the first four sharpening the axe.” In this study,  published in  Metabolic Engineering , a team of …

… learned to adapt from marine to hypersaline conditions by studying the microbial communities in Antarctic lakes, some … shed light on the global biogeography in the haloarchaeal gene pool, a team led by University of New South Wales … Impact By collecting and sequencing dominant haloarchaeal sequences from six hypersaline lakes, researchers focused on …

… Metagenome Program head Emiley Eloe-Fadrosh outline more targeted approaches to reconstruct individual microbes in an … recent Nature Communications paper, uncovering giant virus sequences in soil for the first time. A second approach … and experimental approaches with the aim of eventually studying virus-host dynamics in nature. In the last few …

… Sequence-based studies — from metagenomics to single-cell … methods, researchers have shed light on the genetic makeup of new giant viruses. This review highlights … these viruses via their genomes, paving the way for future targeted isolation efforts and subsequent detailed …