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An Age of CRAGE: Advances in Rapidly Engineering Non-model Bacteria
… applying a method that allows researchers to quickly modify diverse bacterial genomes. In 2019, the JGI’s Yasuo … precise genome editing. This means that scientists can modify gene expression, or delete genes, all with the rapid …
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The More the Merrier: Making the Case for Plant Pan-genomes
… more than once, and these events took place a million years apart: the individual with a maternal  B. distachyon parent (D plastotype) some 1.4 million years ago (Mya), while the S plastotype was a more recent … anticipated with only minor gene loss even after a million years.” Reference genomes for  B. distachyon ,  B. stacei …
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Mapping the Earth’s Hidden Fungal Kingdom
… and lay a future-ready foundation     Over the past billion years, fungi have spread quietly throughout our planet. From … the genus Aspergillus has been evolving for 82 million years, making it nearly 30 times older than the entire human … from diverse fungi, researchers struggle to identify and classify new species from environmental samples. …
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Silver age of GOLD introduces new features
… The JGI’s Genomes OnLine Database celebrates 25 years as a vital resource for data contextualization The Science Since its launch 25 years ago, the  Genomes OnLine Database has matured from six …
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A Better Way to Find RNA Virus Needles in the Proverbial Database Haystacks
… viruses is just the beginning. “I often say that just identifying a sequence as viral is not even half the story.” Neri … of efficient, automated approaches to analyze and classify sequence data at this scale is essential.”   …
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Doubling Down on Known Protein Families
… a dark room with a flashlight, only able to clearly identify what falls within that single beam. When it comes to … but we knew the families,” Kyrpides said. Yet, “almost 20 years of metagenomic data and metagenomic analysis, and … of new protein families had started to plateau in recent years, perhaps suggesting that scientists had “captured” …
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Learning to Look
… databases. In this case, the machine “learned” to identify a certain type of bacterial viruses or phages called … 70,000 microbial and metagenome datasets, ultimately identifying more than 10,000 inovirus-like sequences compared to … you’ve found the right features that you can use to identify the inoviruses.” Overhauling the Perception of Inovirus …
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JGI Earth Month: The Unusual Metabolism That Helps Plants Withstand Drought
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Enlarging Windows into Understanding Gene Functions
… Unique Capability DAP-seq allows researchers to identify all the sites where transcription factors bind quickly … ENCODE project known as FUNCODE. “We noticed a few years ago that there is no shortage of fungal genomes … functional interpretation is as tough as it has been 10 years ago,” he said. “We thought about reconstructing gene …
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The Power of One, Amplified
… in, on, and around the planet remain unknown. In recent years, advances in sequencing technologies and bioinformatic … diverse than those within more moderate ecosystems. A few years ago, a candidate bacterial lineage was identified from …
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DAP-seq Drives Robust Mapping of Gene Regulation
… broccoli and trees like poplar, spanning about 150 million years of evolution,” said Leo Baumgart, first author on the … Advancing gene regulation mapping Previous methods to identify where transcription factors (TFs) — the proteins that … that a binding site has been maintained through millions of years of evolution, suggesting it plays an important …
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Jane Grimwood Named HudsonAlpha Genomics Chair
… the simplest cotton genome ( Gossypium raimondii ) several years ago.   As well as the seminal Human Genome Project DOE …
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