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Revealing reaction intermediates in one-carbon elongation by thiamine diphosphate/CoA-dependent enzyme family
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A distinct class of ferredoxin:NADP+ oxidoreductase enzymes driving thermophilic ethanol production
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RECAP: Keynote Speakers Talk Innovation at 2022 JGI Annual Meeting
… then pivoted towards the future and shared ways that her team is looking to use CRISPR-Cas9 to solve new problems. … genetic sequences (already known as CRISPR) that came up in her team’s metagenomic  samples . While Banfield … relate to inherited traits, and applied it to groundbreaking genetics. This work paved the way to move beyond a …
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JGI@25: From Life at the Extremes to Editing Genomes
… “a revolutionary impact on the life sciences.” Building upon CRISPR-Cas9 work, the Doudna lab at UC Berkeley seeks other enzymes in the CRISPR-Cas system. For the past few years … “These bits of information sent a little shiver of intrigue down my spine; if CRISPR was present in so many different …
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Marchantia Pangenome Highlights Adaptive Nature of Plant Lineages
… involved in adaptations seen in later plant lineages. The team found that some of the adaptation strategies used by … They hypothesized that certain gene families — including fungal genes horizontally transferred — contributed to the … repeats (NLRs) —stood out for their roles. Peroxidases are enzymes known to help a plant to adapt to environmental …
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Mining Metagenomes for Cas Proteins
… The sequences were then biochemically characterized by a team led by Jennifer Doudna’s group at the University of California (UC), Berkeley, which is … in CRISPR sequences to target the virus and release attack enzymes in the form of Cas enzymes to cut the DNA and …
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Anuvia taps JGI for expertise to pinpoint products from beneficial soil microbes
… The practices that support agriculture – such as efficiently using dwindling water resources and restoring … National Laboratory, is committed to advancing genomics in support of DOE missions related to clean energy generation and environmental characterization and cleanup. The JGI provides integrated high-throughput sequencing …
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CreA-mediated repression of gene expression occurs at low monosaccharide levels during fungal plant biomass conversion in a time and substrate dependent manner
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The Genomes of the Fungal Plant Pathogens Cladosporium fulvum and Dothistroma septosporum Reveal Adaptation to Different Hosts and Lifestyles But Also Signatures of Common Ancestry
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Genomics and Transcriptomics Analyses of the Oil-Accumulating Basidiomycete Yeast Trichosporon oleaginosus: Insights into Substrate Utilization and Alternative Evolutionary Trajectories of Fungal Mating Systems
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A telomere-to-telomere genome assembly resource of Bipolaris sorokiniana, the fungal pathogen causing spot blotch and common root rot diseases in barley and wheat
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Integrative genomic mining for enzyme function to enable engineering of a non-natural biosynthetic pathway
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