Results

Uncovering Novel Genomes from Earth’s Microbiomes
Large-scale comparative analysis leads to identification of biosynthetic gene clusters for novel secondary metabolites for multiple applications.   … public Narrative , which provides shareable, reproducible workflows. “Metabolic modeling is a routine analysis for …
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Trent Northen
Dr. Northen is currently a Senior Staff Scientist at Berkeley Lab. Since joining … K et al . EcoFAB: Advancing microbiome science through standardized fabricated ecosystems. Nature Methods (16), … … Metabolomics Science Program … Education … Selected Publications … Awards and Honors …
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A Redesign for Yeast’s Genome, Chromosome by Chromosome
To engineer yeast to do more, and understand genomes in general, Jef Boeke, Weimin Zhang … have worked to replace yeast’s native chromosomes with synthetic versions. This project has turned out to be an …
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Restoration of biofuel production levels and increased tolerance under ionic liquid stress is enabled by a mutation in the essential Escherichia coli gene cydC
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Modulation of sensory perception by hydrogen peroxide enables Caenorhabditis elegans to find a niche that provides both food and protection from hydrogen peroxide
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JGI-Enabled Research Demonstrates the Existence of New Methane-Makers
New studies show methanogenesis is not exclusively for Euryarchaeota. Atmospheric levels of methane, a potent … these little makers rely on to survive. Now, new research enabled by the U.S. Department of Energy (DOE) Joint Genome …
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Single mutation at a highly conserved region of chloramphenicol acetyltransferase enables isobutyl acetate production directly from cellulose by Clostridium thermocellum at elevated temperatures
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A Grass Model to Help Improve Giant Miscanthus
Miscanthus  sequence offers insights into benefits of polyploidy … The Science A reference genome sequence and genomic toolkit for the perennial grass  Miscanthus sinensis has been … and Environmental Research under Award Number DE-SC0018420. The work conducted by the U.S. Department of Energy …
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A Synthetic Gene Library Yields a Previously Unknown Glycoside Phosphorylase That Degrades and Assembles Poly-β-1,3-GlcNAc, Completing the Suite of β‑Linked GlcNAc Polysaccharides
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Busting the Unbreakable Lignin
New evidence shows anaerobic fungi can degrade the hardiest of plant components … to tackle when it comes to breaking down a plant for energy: Cellulose, hemicellulose and lignin, … of the types of chemical bonds in plant cell walls, it enabled researchers to identify specific bond-breakages …
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How Filamentous Fungi Sense Food
Tracing gene regulatory networks in the model fungus  … Science A team led by researchers at the University of California, Berkeley used a multi-omics approach to reconstruct … Berkeley National Laboratory (Berkeley Lab). The work was enabled in part through JGI’s Community Science Program …
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Nikos Kyrpides
Kyrpides joined the DOE Joint Genome Institute in 2004 to lead the Genome Biology Program and the development of the comparative analysis platforms for microbial genomes and metagenomes (IMG). He became … Thousands of Small, Novel Genes. Cell. 178(5):1245-1259. Publications on Pubmed | Google Scholar … Thomson Reuters …
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