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Single mutation at a highly conserved region of chloramphenicol acetyltransferase enables isobutyl acetate production directly from cellulose by Clostridium thermocellum at elevated temperatures
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Marcel Huntemann
Marcel is in charge of several production pipelines (gene calling, functional annotation … that run on microbial genomes and metagenomes. He also works on automating intra-department data exchange and assists with …
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Game On: High School Students Drive Everglades Metagenomics Study
Sample Management Group, attended a conference in Florida to discuss a JGI pilot project involving soil sampling in … of genes involved in environmentally significant metabolic pathways related to methane production, nitrogen fixation, and dissimilatory sulfite …
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Taking Stock of the Known and Unknown Microbial Space
… help map out microbial diversity hotspots Over the past few decades, advancements in sequencing technologies have led to an abundance of microbial genomes becoming available to … of the microbial diversity we know about, and proposes a path forward to curate and cultivate what is still unknown.  …
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JGIota: A Biofuel Breakthrough in Anaerobic Fungi with Michelle O'Malley and Tom Lankiewicz
Michelle O’Malley and Tom Lankiewicz of UC Santa Barbara discuss the importance of studying … presumption on its head and opens up a new avenue to explore for efficient biofuel production. …
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How to Target a Microbial Needle within a Community Haystack
A workflow for capturing the genetic make-up of specific … Microbiology has developed, tested and deployed a pipeline to first target cells from communities of uncultivated … development, and researchers found that ethanol treatment improved fluorescence signals without hampering subsequent …
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Partnerships: Myco-Ed
… fungal biology teaching labs. The purpose of the program is to: train students and professors in laboratory techniques … original data for improving fungal genomic resources empower students through isolation and genome sequencing of new … exercises … Beyond providing a scalable solution for production of high-quality fungal reference genomes, this …
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JGI@25: Following Fungi that Pry Apart Plant Polymers
… that showcase our collaborations and capabilities to enable great science that will help solve energy and … tools beyond biomass breakdown, extending into biochemical production.    Over time, as these projects have delivered … and porting parts from nature — enzymes, transporters, pathways — into microbes that we do know, to advance our …
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JGI@25: Cow Rumen and the Early Days of Metagenomics
In honor of the JGI's 25th anniversary in 2022, we have revisited a number of notable achievements that showcase our collaborations and capabilities to enable great science that will help solve energy and … study subject that could lead to more sustainable energy production.  However, less than 10% of the microbes found in …
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Inspiring STEM Careers Through a Hands-on Everglades Microbiome Study
Journal publication caps JGI pilot project with fledgling Florida high school scientists. The Florida … evokes images of fanboats skimming over swamps, while alligators peer through the waters and clouds of insects hover … to give his students this experience. My current career path was heavily influenced by my own high school biology …
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Natural Prodcast Episode 6: Marc Chevrette
… … DAN: You’re listening to the US. .Department of Energy Joint Genome Institute’s … and scientists of secondary metabolism.  DAN: Hi again, and welcome to Episode 6 of Natural Prodcast. What you’re going … breaking our methods was these damn secondary metabolite pathways. So that’s kind of how I fell down the rabbit hole. …
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DOE Metrics
FY 2025 DOE Metrics Sequencing Quarter Total Bases (Trillions) Operating Hours Goal Actual Total* … of the total available hours.   FY 2024 DOE Metrics There were 2,456 unique* JGI users in FY2024 , which includes … System (LIMS) and temporary shut down of the sequencing production line to accommodate data migration requirements. …
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