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Uncovering Novel Genomes from Earth’s Microbiomes
… Large-scale comparative analysis leads to identification of biosynthetic gene clusters for novel secondary … have uncovered genomes for just a small fraction of Earth’s microbial diversity. Because most microbes cannot … microbial diversity is key to understanding the roles of microorganisms in regulating nutrient cycles, as well as …
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Busting the Unbreakable Lignin
… New evidence shows anaerobic fungi can degrade the hardiest of plant components   The Science There are three main … it comes to breaking down a plant for energy: Cellulose, hemicellulose and lignin, cumulatively called lignocellulose, are the primary components of hardy cell walls. It’s the cellulose and hemicellulose …
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GenomeOcean Leverages AI to Decode Nature’s Secret Language
… genome discoveries. Unlocking the intricate details of life’s genetic blueprint has long been a significant … analyze but also create DNA sequences mimicking an array of microbial life. By leveraging massive user-generated … a similar manner. From the gene, we have those regulatory elements like promoters in front of this protein coding …
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An Age of CRAGE: Advances in Rapidly Engineering Non-model Bacteria
… ( CRAGE ). CRAGE enables scientists to insert large pieces of DNA (up to 60 kb) in a single step, directly into the genome. “CRAGE is central to our ability to offer host-engineering for our users,” says JGI Director … Cas9 with CRAGE in  PLOS One , engineering different gene deletions in four gammaproteobacterial species, and then …
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JGI Scientists Pen Genome Watch Articles
… more to come in 2020. Researchers at the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User Facility located at Lawrence Berkeley … The U.S. Department of Energy Joint Genome Institute, a DOE Office of Science User Facility  located at Lawrence …
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Simon Roux
… the JGI in 2017 to lead viral genomics research as part of the Metagenome Program. His responsibilities include the development of novel computational tools to identify virus sequences, the design of new experimental approaches to link viruses to their … Neri et al., 2023. Expansion of the global RNA virome reveals diverse clades of …
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Jane Grimwood Named HudsonAlpha Genomics Chair
… Biotechnology! Loretta Spencer served as a manyterm mayor of Huntsville, Alabama and is known for her contributions to … large-scale multi-institutional JGI projects and resulting publications that Grimwood contributed to include: A 2021 … As well as the seminal Human Genome Project DOE Chromosome publications: The DNA sequence and biology of human …
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Designer DNA: JGI Helps Users Blaze New Biosynthetic Pathways
… A special issue of Synthetic Biology celebrates research enabled by the JGI … and synthesis work. This is where the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office … more than 10 papers, including two Nature Plants publications, in five years, have come out of the …
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The Soil Blooms Green
… Every fall, a mysterious green growth appears on top of farmers’ fields: a microbial community that might be …
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MGM Workshop at Fisabio Summer School
… Workshop The workshop is addressed to students and professionals of biology, biomedical research, the health sciences and … microbiome. The workshop will train participants in state-of-the-art analytical methods in this area, by means of …
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JGIota: Looking Back at Sequencing for Soybeans
… The soybean is a crop that could boost biofuels and fertilize fields. So in 2010, the JGI helped … about that work from researchers Gary Stacey (University of Missouri), Peter van Esse (The Sainsbury Laboratory) and …
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MGM Workshop at Fisabio Summer School 2025
… Register here The workshop is addressed to students and professionals of biology, biomedical research, the health sciences and … microbiome. The workshop will train participants in state-of-the-art analytical methods in this area, by means of …
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