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… about natural products you’ll get a good sense of what it’s like working with him.  We talk about his father, the … then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … miners use, including antiSMASH, MIBiG, and newer efforts, like BiG-scape and BiG-SLiCE, and now the BiG-FAM database … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean …

… and scientific research, especially at US National Labs, like Lawrence Berkeley Lab (that’s LBL), the National Lab … at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these …

… Overview The JGI provides sequencing, synthesis, and targeted metabolomics support for DOE-BER funded awards, … capabilities and products . A minimum request of 1 Tb of sequence data is required to qualify for BERSS. For DNA … The JGI is inviting researchers using the U.S. Culture Collection Network (USCCN) to …

… And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … consortia of microorganisms growing on the walls. They look like– they look like colonies, different colors, all sorts …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … hear about something I’ve been working on for what feels like forever, and we also recorded a proper introduction … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. …

… Joint Genome Institute is to serve the scientific community as a user facility pioneering functional genomics to solve the most … The researcher then submits a proposal for consideration in the next review cycle. All … For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on …

… be coming out on the first Thursday of the month, just like I promised. Now I just have to make this whole “on-time … The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain …

… got into secondary metabolites? Kate Duncan: So I always liked science in school. I wouldn’t say I was one of these … Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the …

… Apple Podcasts or wherever you’re getting this and tell me why you’re listening. DAN: But, now, here’s Natural Prodcast … was the chance to see what the industrial life was like. And I think I learned that I’m more of an academic … And that’s been followed by developments in pulse sequences and improvements in the ways in which you acquire …

… of academia, or if you want to understand what it’s like to do field science as a woman and with a physical … culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … methicillin-resistant Staphylococcus aureus . Can you share why finding treatments for these microbes is so important? …

… DAN: Hello, everyone, and Welcome back for Episode 14 of … other JGI staff about secondary metabolism or anything you like. It should be really fun and interesting, so I hope … to some people more about down the road. Email Nigel! He’ll sequence whatever you want!  [LAUGHTER]  NIGEL MOUNCEY: We …