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Overview The JGI provides sequencing, synthesis, and targeted … capabilities and products . A minimum request of 1 Tb of sequence data is required to qualify for BERSS. For DNA … and personnel resources for genomic research and sequence-based science.  Projects include de novo generation …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … compounds, again, that were different, different structure types. We started amassing a collection of marine bacteria. … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… … DAN: You’re listening to the US Department of Energy Joint Genome … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … more about some of the background and sort of the reasons why we want to do this. And also to provide a little more …

… large microbes. And they have all sorts of cool phenotypes that you can visualize by your eye. So one thing I … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … And yeah, so the tundripaludum part there comes– the type strain was isolated from Svalbard Norway so right there …

Apple Podcasts or wherever you’re getting this and tell me why you’re listening. DAN: But, now, here’s Natural Prodcast … doing natural products isolation/structure elucidation type work. DAN: Yeah, that’s right. I want to talk about … And that’s been followed by developments in pulse sequences and improvements in the ways in which you acquire …

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … And we know what’s in that. And you have these different types of particulate like 2.5, 10 PPMs and just the size of … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

Eukaryotic projects: Kerrie Barry or Vivian Ng Prokaryotic projects: … pages for details.  … Who is my project manager? … What types of products does the JGI offer? … How do I submit a … I request a culture/slant/DNA of an organism that has been sequenced at the JGI? … How do I check the current status of …

The Synthetic Biology lab is divided into a DNA synthesis production … We focus our efforts on integrating database mining and sequence design with scaling the production of large, … methodologies, and statistical frameworks for inferring genotype to phenotype associations. Research Team    … For …

And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … They’re not sealed off and closed. But there’s definitely types of organisms that are living there. And we’ve moved …

… able to explore DNA sequencing and actually get to the DNA sequence – sequences for the genes that code for the … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less … very expensive and very difficult. And it turns out some types of natural product pathways are really difficult to …

Our research is focused on the discovery and characterization of novel bacterial, archaeal … and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, …