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… For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on a regular basis, in accordance with …

… at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these … our process and we’ll have it off to you within 90 days. Three months. We offer 5 to 10 kb size synthesis. We offer …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … bigger and better for eventually one of antiSMASH with the three of us, but unfortunately we didn’t know about that. …

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a … how to look at the different Frankia genomes. And we had three genomes. We did comparative analysis. We did structure …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … has developed a system. It’s relatively simple. So there’s three members, there’s a Bacillus , there’s a …

… wear my prosthetic leg. I had my leg amputated when I was three and almost died of an infection following the … culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … methicillin-resistant Staphylococcus aureus . Can you share why finding treatments for these microbes is so important? …

… does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … able to produce chemistry that deals with reactive oxygen species and so potentially could go down that route.  DAN: … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

… and annotation of all publicly available genomes from three domains of life, in a uniquely integrated context.  … comprising the largest public collection of plasmid sequences identified from genomes, SAGs, MAGs, metagenomes …

… Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … Right. Kate Duncan: And Pseudonocardia . And we’ve got new species which we’re currently in the process of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the …

… through isolation and genome sequencing of new fungal species.  Students collect fungi, sterilize tissue, isolate … and distribution of fungal genome datasets. It includes JGI-sequenced and publicly available datasets encompassing a … and researchers, facilitating the transition from genomic sequences to biological inference and understanding of …

… shown today is it's more a quorum sensing within a single species. DAN: Within a species. Genus? BETSY PARKINSON: So … The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain …

… and environmental sustainability. Fungi, with million species, are essential for ecosystem functioning — … The  1000 Fungal Genomes Project is a five-year project to sequence 1000 fungal genomes from across the Fungal Tree of … of fungi. Mycocosm enables users to navigate across sequenced fungal genomes, and to conduct comparative and …