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… systems. No one was, at that time, really working with microbes from the ocean. So I felt there was a wonderful … then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … you think about the fact that, when plants and animals and microbes evolve, they evolve to make molecules that improve … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … a nice example of going from a whole community with many microbes, hundreds of gene clusters, and then being able to …

… And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … them on a regular basis. So they are full of terrestrial microbes. So they’re open ecosystems. They’re not sealed off …

… processes, development of high performance plants and microbes, and understanding microbiome interactions. The  … insights into how small molecules function within plants, microbes, and ecosystems. Identifying and analyzing primary … range of biological and environmental samples — including microbes, fungi, plants and soils. Through a combination of …

… be accessed via the Genome Portal , at the following sites: Microbes: IMG (citation: https://doi.org/10.1093/nar/gkaa939 … I request a culture/slant/DNA of an organism that has been sequenced at the JGI? …

… capabilities and products . A minimum request of 1 Tb of sequence data is required to qualify for BERSS. For DNA … and personnel resources for genomic research and sequence-based science.  Projects include de novo generation …

… embargo starting at construct or strain delivery.  Detailed sequence information and constructs are made publicly …

… you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … I’ve seen you give a few talks on that. Can you tell us why cone snails are so cool? ERIC:  So cone snails are … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… capabilities support researchers exploring how to convert sequence into functional assessments. This is done by … BOOST provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination …

… In the ocean’s North Pacific Subtropical Gyre, microbes tend to stay localized at different depths. But … of SAR324 cells and their gene expression, the team then sequenced community genomes and expressed gene transcripts … ecotypes because, historically, they have used the sequence of a “marker gene,” namely the 16S ribosomal RNA …

… what’s important in terms of the chemistry produced by microbes. And by what’s important, I mean, like, where … Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the …