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… least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … could call things such that the terms will be useful. The community– we should say that. I mean, we just proposed … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

… the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very … genomic revolution, to me, as a natural part chemist for microbial natural product, is that I love microbial natural …

… there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think … fascinating, I think. DAN UDWARY: Yeah, and that was a JGI Community Sequencing Project. You’re right, yeah. NADINE … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger …

… you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … do you think it was about that? What factors led to the community – not necessarily competing, but – sort of, diving … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… As a National User Facility, the JGI serves more than 2,500 users that predominately come from the public sector: academic and government institutions … Our metabolomics platform delivers rich metabolite profiles from diverse biological and environmental samples by using …

… of the Joint Genome Institute is to serve the scientific community as a user facility pioneering functional genomics to solve the … The researcher then submits a proposal for consideration in the next … The ranked proposal list, along with a recommendation from management at JGI and the other participating …

… Microbes drive critical ecosystem functions and affect global nutrient cycling, however they do so under … parameters driving virus:host dynamics in environmental microbial communities. This involves both experimental and … of phage and virus genomes have been assembled and reported from metagenomes, our understanding of the impacts of these …

… I did my undergraduate in microbiology and then PhD in microbial genetics in the UK. And came across to the US for … product as we think about them in the natural products community, but it was again another product, an organism … to some people more about down the road. Email Nigel! He’ll sequence whatever you want!  [LAUGHTER]  NIGEL MOUNCEY: We …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … Canada. I just got back from a conference in Canada on antimicrobial resistance sponsored by the Garner foundation. And …

… Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the … And sometimes, in terms of biological activities– like antimicrobial or something– sometimes a little difference is …

… enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh … that. Even having that kind of data and sharing it with the community though can help inform how synthetic chemists …

… The JGI’s DNA Synthesis Program supports a wide range of projects, from single-gene synthesis to the synthesis of entire … The DNA Synthesis Program plays a central role in advancing … Program aims to generate large datasets to explore sequence-function relationships, advancing the discovery of …