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… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … a nice example of going from a whole community with many microbes, hundreds of gene clusters, and then being able to …

… And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … them on a regular basis. So they are full of terrestrial microbes. So they’re open ecosystems. They’re not sealed off …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … you think about the fact that, when plants and animals and microbes evolve, they evolve to make molecules that improve … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… As a National User Facility, the JGI serves more than 2,500 users that predominately come from the public sector: academic and government institutions — with capabilities that had remained largely … User Programs entail a competitive, proposal-based process including peer review. The process is streamlined, with …

… what’s important in terms of the chemistry produced by microbes. And by what’s important, I mean, like, where … Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the …

… culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … and take soil and discover a new important drug from the microbes in that soil, there are now international … methicillin-resistant Staphylococcus aureus . Can you share why finding treatments for these microbes is so important? …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

…   The Joint Genome Institute's Biodesign Platform capabilities support researchers exploring how to convert sequence into functional assessments. This is done by … Check out our organism-agnostic CRISPR gRNA design tool  … BOOST provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … able to explore DNA sequencing and actually get to the DNA sequence – sequences for the genes that code for the … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … ecology community to be able to better predict how their microbes are interacting with each other from sequence …

… Eukaryotic projects: Kerrie Barry or Vivian Ng Prokaryotic projects: Tijana Glavina del Rio , Danielle Graham , or Miranda Harmon-Smith DNA … You can visit the Products & Offerings section of our website for … The majority of JGI projects come from the user community. Find out about JGI’s calls for proposals , and submit your …

… Overview The JGI provides sequencing, synthesis, and targeted metabolomics support for DOE-BER funded awards, … capabilities and products . A minimum request of 1 Tb of sequence data is required to qualify for BERSS. For DNA … The JGI is inviting researchers using the U.S. Culture Collection …