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… The mission of the Joint Genome Institute is to serve the scientific community as a user facility pioneering functional genomics to solve the most relevant bioenergy and environmental … Energy Research Scientific Computing Center ( NERSC ) is to accelerate scientific discovery at the DOE Office of …

… fascinating. And I fell in love with actinomycetes. I loved approaching biology from a chemistry background. Dan Udwary: … Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the …

… The CSP New Investigator Call is for investigators and research initiatives new … will provide pilot data to assess feasibility of a novel approach or form the foundation for a large-scale CSP proposal submission. Sequence requests should not exceed 3 Tb in total. Proposals …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … the system. [ Go here to learn more about Cameron Currie’s metagenomics research, enabled in part by JGI’s Community …

… capabilities and products . A minimum request of 1 Tb of sequence data is required to qualify for BERSS. For DNA synthesis requests, the … request falls below these thresholds, you will need to utilize a core facility instead. Proposals may not exceed … using the U.S. Culture Collection Network (USCCN) to nominate their strains for sequencing, as long as they …

… enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh … up, which is maybe not surprising. And so taking this approach of using the– predicting the ancestors that could …

… than 2,500 users that predominately come from the public sector: academic and government institutions — with … largely unknown and underutilized by industry. When Director Nigel Mouncey joined the JGI in 2017, he brought with … him 20 years of industry experience — and an opportunity to expand the JGI’s portfolio of user companies. Now the …

… a wide range of projects, from single-gene synthesis to the synthesis of entire chromosomes, advancing the … collaboration with U.S. and international scientists to drive innovations that align with DOE's missions. … Program aims to generate large datasets to explore sequence-function relationships, advancing the discovery of …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … we noticed that BiG-SCAPE was very scalable compared to approaches before that. But when you wanted to include more …

… you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … that’s making these compounds? So in the end, we took an approach that was kind of a simplified metagenome sequencing … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… See below for examples of successful Letters of Intent to our Community Science Program Large-Scale Call, as well as successful submissions to our CSP New Investigator, CSP Functional Genomics, and Facilities Integrating … Linking lignin engineering to drought stress resilience: RNA-seq and metabolomic …

… then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against … Patrick would spend time between our two laboratories doing metagenomics, some genomics. We were a little concerned …