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… that had remained largely unknown and underutilized by industry. When Director Nigel Mouncey joined the JGI in … national security and ensure U.S. energy dominance by integrating supercomputers, datasets and AI agents to … profiles from diverse biological and environmental samples by using advanced computer analysis coupled with liquid …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … home. Or actually not my room, it’s the room of my little baby daughter, who inherited this room from her sister. And it … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean …

… you bring a unique perspective too? And so I was fascinated by – we spend a lot of time as natural products chemists and … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … genetic differences and then expanded on on that knowledge by doing a second postdoc with Yi Tang at UCLA and then kind … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

… And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … just– and then in terms of there’s sequencing an organism by shotgun, which is what we did, we didn’t even sequence …

… more about Tiny Earth and the JGI’s role in the project by watching Amanda Hurley’s presentation from the 2019 JGI … at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways …

… like a lot of people hedge their way into natural products by starting out in synthesis and then discovering more-- … The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain …