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… Udwary. I – as well as my co-host, Alison Takemura, whose voice you’ll hear in a minute – we work for the US Department … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … more about some of the background and sort of the reasons why we want to do this. And also to provide a little more …

… program. MENAKA WILHELM: How cool. And I think that’s a nice segue for the next thing we wanted to ask you about, … at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these …

… partnership with Berkeley Lab’s Strategic Partnerships Office and Intellectual Property Office to execute agreements. Learn more about partnering with … own inventions and have the first right to negotiate a license to Lab inventions generated.  … our User Program’s Community Science Program, the JGI sequenced and characterized 270 genomes of the Clostridium …

… I worked at a high school. And one of the things that I noticed is all the food that the students got was coming from … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …

… know. Second, I want to take a minute to introduce a new voice to the Prodcast. Please take a second to join me in … And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, …

… then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against … I have – in at least the last, you know, many years – noticed how many different kinds of projects and how many great …

… capabilities support researchers exploring how to convert sequence into functional assessments. This is done by … BOOST provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … it’s very situational. And every microbe is a special snowflake. So… ALISON: Yeah, I mean, would you say that all …

… able to explore DNA sequencing and actually get to the DNA sequence – sequences for the genes that code for the … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less … that if you wanted to say synthesize this thing… Do you notice anything in particular about those squares? Those …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … of California San Diego. I walked into the director’s office, asked him if I could speak to him. And I said, you … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain … through and transcribe the genes downstream. JACKIE: Very nice. DAN: And then just to make this abundantly clear to our …

… resequencing, RNA sequencing and epigenomics. Expansion of sequence space:  The JGI generates reference genomes from … of microbial communities based on their metagenome sequence, in the context of reference isolate genomes …