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Welcome back to Natural Prodcast. This continues the series of interviews we recorded at the Society for Industrial … enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

… initiatives new to the JGI. Projects must be independent of ongoing JGI proposals, and lead PIs cannot have been lead … the foundation for a large-scale CSP proposal submission. Sequence requests should not exceed 3 Tb in total. Proposals … accepted proposals, sequencing, synthesis, metabolomics and analysis will be paid for by the Department of Energy’s …

… at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these … into our integrated microbial genomes system, which is our comparative analysis system. Once that is completed, the …

Secondary Metabolites Program focuses on the exploration of secondary metabolites across bacteria, fungi, algae and … biosynthetic gene clusters (BGCs), advancing pathway analysis, optimization of cell- and cell free-based … computational analyses of BGC size and complexity, BGC sequence composition, metabolic similarity & compatibility, …

… out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk … Then you have to maybe improve some of your bioinformatic analysis. You don’t want to get clusters that are encoding …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

DNA design and synthesis, metabolomics and computational analysis that enable systems-based scientific approaches to … in doing so enabled the JGI to be the first to publish the sequence analysis of the target chromosomes 5, 16, and 19, … scientific discovery. Projects focused on organisms for comparative purposes, on model systems for microbe-microbe …

… here today, and we wanted to talk to her about a whole list of things. So we have a Scripps background shared together, … Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … pellets. So, we’re about ready to send those for genomic analysis. And of course, we don’t know anything about the … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … at MIT, and I studied microbial ecology. I studied Vibrio species in the ocean, so heterotrophic bacteria. Now, we …

Christa Pennacchio   … You can visit the Products & Offerings section of our website for more details, including … metadata about the samples, and the sample QC results. … Analysis and annotation of publicly available projects can … I request a culture/slant/DNA of an organism that has been sequenced at the JGI? … How do I check the current status of …

Program aims to generate large datasets to explore sequence-function relationships, advancing the discovery of … … The IMG/M system serves as a community resource for comparative analysis and annotation of all publicly available genomes …