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… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast– a … least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

… functional genome annotation, improves understanding of the role small molecules play in diverse biological … sheds light on nutrient cycling, and leads to the discovery of new molecules and pathways. The JGI Metabolomics Platform … based methods in combination with advanced computational analysis.   Overview of metabolomics products At JGI, …

… Welcome back to Natural Prodcast. This continues the series of interviews we recorded at the Society for Industrial … enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

… capabilities support researchers exploring how to convert sequence into functional assessments. This is done by … and novel automations for DNA design, assembly and analysis Overview of biodesign products The JGI Biodesign platform enables … BOOST provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination …

… at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these … into our integrated microbial genomes system, which is our comparative analysis system. Once that is completed, the …

… out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk … Then you have to maybe improve some of your bioinformatic analysis. You don’t want to get clusters that are encoding …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… Secondary Metabolites Program focuses on the exploration of secondary metabolites across bacteria, fungi, algae and … advantages to the organisms producing them, and are often involved in defense, nutrient acquisition and … their potential applications in the bioeconomy including biofuels, biochemicals and sustainable agriculture. …

… here today, and we wanted to talk to her about a whole list of things. So we have a Scripps background shared together, … Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … pellets. So, we’re about ready to send those for genomic analysis. And of course, we don’t know anything about the … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… You can visit the Products & Offerings section of our website for more details, including a downloadable pdf of products categorized by Science Program.  … The majority of JGI projects come from the user community. Find out about … proposal calls and proposal submission, as well as examples of approved proposals, please visit the Proposals FAQ .  …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … at MIT, and I studied microbial ecology. I studied Vibrio species in the ocean, so heterotrophic bacteria. Now, we …